open access

Vol 16, No 5 (2009)
Case Reports
Published online: 2009-07-31
Submitted: 2013-01-14
Get Citation

Acute myocardial infarction in a patient with hemophilia A and factor V Leiden mutation

Meral Günaldi, Aysen Helvaci, Naciye Demirel Yildirim, Muharrem Kiskaç, Reyhan Diz Küçükkaya
Cardiol J 2009;16(5):458-461.

open access

Vol 16, No 5 (2009)
Case Reports
Published online: 2009-07-31
Submitted: 2013-01-14

Abstract

Factor VIII:C, epsilon amino-caproic acid or tranexamic acid are prophylactic agents used in preventing hemorrhage pre-operatively in patients with hemophilia A. Although hemophilia A seems to be a factor that avoids the development of acute myocardial infarction (AMI) as it tends to be associated with increased bleeding, it should be kept in mind that prothrombotic agents used pre-operatively for prophylaxis may increase the risk for AMI in the presence of the factor V Leiden mutation. In this report, we discuss the development of AMI following the use of recombinant factor VIII and tranexamic acid for prophylaxis in a patient with known hemophilia before a tooth extraction in conjunction with the relevant literature.

Abstract

Factor VIII:C, epsilon amino-caproic acid or tranexamic acid are prophylactic agents used in preventing hemorrhage pre-operatively in patients with hemophilia A. Although hemophilia A seems to be a factor that avoids the development of acute myocardial infarction (AMI) as it tends to be associated with increased bleeding, it should be kept in mind that prothrombotic agents used pre-operatively for prophylaxis may increase the risk for AMI in the presence of the factor V Leiden mutation. In this report, we discuss the development of AMI following the use of recombinant factor VIII and tranexamic acid for prophylaxis in a patient with known hemophilia before a tooth extraction in conjunction with the relevant literature.
Get Citation

Keywords

hemophilia A; myocardial infarction; factor V Leiden mutation

About this article
Title

Acute myocardial infarction in a patient with hemophilia A and factor V Leiden mutation

Journal

Cardiology Journal

Issue

Vol 16, No 5 (2009)

Pages

458-461

Published online

2009-07-31

Bibliographic record

Cardiol J 2009;16(5):458-461.

Keywords

hemophilia A
myocardial infarction
factor V Leiden mutation

Authors

Meral Günaldi
Aysen Helvaci
Naciye Demirel Yildirim
Muharrem Kiskaç
Reyhan Diz Küçükkaya

Important: This website uses cookies.tanya dokter More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk, Poland
tel.:+48 58 320 94 94, fax:+48 58 320 94 60, e-mail: viamedica@viamedica.pl