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Correlation between CD34+ and exercise capacity, functional class, quality of life and norepinephrine in heart failure patients
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Abstract
Background: A previous study associated CD34+ levels with NYHA functional class in heart failure patients. The aim of this study was to correlate CD34+ levels to exercise capacity, functional class, quality of life and norepinephrine in heart failure patients.
Methods: Twenty three sedentary patients (52 ± 7 years, 78% male) answered the Minnesota Living with Heart Failure Questionnaire and rested for 20 minutes before an investigator collect a blood sample. After this, patients performed a cardiopulmonary exercise test to determine the heart rate at anaerobic and ventilatory threshold and oxygen consumption at peak effort, at anaerobic and ventilatory threshold. One other blood sample was collected during the peak effort to investigate the norepinephrine and CD34+ levels.
Results: Rest percentage of CD34+ did not show correlation with: left ventricle ejection fraction (r = 0.03, p = 0.888), peakVO2 (r = 0.32, p = 0.13), VO2 at anaerobic threshold (VO2AT) (r = 0.03, p = 0.86), VO2 at ventilatory threshold (VO2VT) (r = 0.36, p = 0.08), NYHA functional class (r = –0.2, p = 0.35), quality of life (Minnesota) (r = –0.17, p = 0.42). CD34+ did not show correlation, either, with: peakVO2 (r = 0.38, p = 0.06), VO2AT (r = 0.09, p = 0.65), VO2VT (r = 0.43, p = 0.4), NYHA functional class (r = –0.13, p=0.54), quality of life (r = 0.00, p = 0.99).
Conclusions: CD34+ levels did not correlate with exercise capacity, functional class, quality of life and norepinephrine. Percentage of CD34+ levels did not increase during the cardiopulmonary exercise test in heart failure patients.
Abstract
Background: A previous study associated CD34+ levels with NYHA functional class in heart failure patients. The aim of this study was to correlate CD34+ levels to exercise capacity, functional class, quality of life and norepinephrine in heart failure patients.
Methods: Twenty three sedentary patients (52 ± 7 years, 78% male) answered the Minnesota Living with Heart Failure Questionnaire and rested for 20 minutes before an investigator collect a blood sample. After this, patients performed a cardiopulmonary exercise test to determine the heart rate at anaerobic and ventilatory threshold and oxygen consumption at peak effort, at anaerobic and ventilatory threshold. One other blood sample was collected during the peak effort to investigate the norepinephrine and CD34+ levels.
Results: Rest percentage of CD34+ did not show correlation with: left ventricle ejection fraction (r = 0.03, p = 0.888), peakVO2 (r = 0.32, p = 0.13), VO2 at anaerobic threshold (VO2AT) (r = 0.03, p = 0.86), VO2 at ventilatory threshold (VO2VT) (r = 0.36, p = 0.08), NYHA functional class (r = –0.2, p = 0.35), quality of life (Minnesota) (r = –0.17, p = 0.42). CD34+ did not show correlation, either, with: peakVO2 (r = 0.38, p = 0.06), VO2AT (r = 0.09, p = 0.65), VO2VT (r = 0.43, p = 0.4), NYHA functional class (r = –0.13, p=0.54), quality of life (r = 0.00, p = 0.99).
Conclusions: CD34+ levels did not correlate with exercise capacity, functional class, quality of life and norepinephrine. Percentage of CD34+ levels did not increase during the cardiopulmonary exercise test in heart failure patients.
Keywords
exercise capacity; CD34+; quality of life; functional class; norepinephrine; stem cell
About this articleTitle
Correlation between CD34+ and exercise capacity, functional class, quality of life and norepinephrine in heart failure patients
Journal
Issue
Pages
426-431
Published online
2009-07-31
Page views
1472
Article views/downloads
990
DOI
10.5603/cj.21457
Bibliographic record
Cardiol J 2009;16(5):426-431.
Keywords
exercise capacity
CD34+
quality of life
functional class
norepinephrine
stem cell
Authors
Vitor Oliveira Carvalho
Milton Artur Ruiz
Edimar Alcides Bocchi
Vagner Oliveira Carvalho
Guilherme Veiga Guimarães
