open access

Vol 16, No 5 (2009)
Original articles
Published online: 2009-07-31
Submitted: 2013-01-14
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Correlation between CD34+ and exercise capacity, functional class, quality of life and norepinephrine in heart failure patients

Vitor Oliveira Carvalho, Milton Artur Ruiz, Edimar Alcides Bocchi, Vagner Oliveira Carvalho, Guilherme Veiga Guimarães
Cardiol J 2009;16(5):426-431.

open access

Vol 16, No 5 (2009)
Original articles
Published online: 2009-07-31
Submitted: 2013-01-14

Abstract


Background: A previous study associated CD34+ levels with NYHA functional class in heart failure patients. The aim of this study was to correlate CD34+ levels to exercise capacity, functional class, quality of life and norepinephrine in heart failure patients.
Methods: Twenty three sedentary patients (52 ± 7 years, 78% male) answered the Minnesota Living with Heart Failure Questionnaire and rested for 20 minutes before an investigator collect a blood sample. After this, patients performed a cardiopulmonary exercise test to determine the heart rate at anaerobic and ventilatory threshold and oxygen consumption at peak effort, at anaerobic and ventilatory threshold. One other blood sample was collected during the peak effort to investigate the norepinephrine and CD34+ levels.
Results: Rest percentage of CD34+ did not show correlation with: left ventricle ejection fraction (r = 0.03, p = 0.888), peakVO2 (r = 0.32, p = 0.13), VO2 at anaerobic threshold (VO2AT) (r = 0.03, p = 0.86), VO2 at ventilatory threshold (VO2VT) (r = 0.36, p = 0.08), NYHA functional class (r = –0.2, p = 0.35), quality of life (Minnesota) (r = –0.17, p = 0.42). CD34+ did not show correlation, either, with: peakVO2 (r = 0.38, p = 0.06), VO2AT (r = 0.09, p = 0.65), VO2VT (r = 0.43, p = 0.4), NYHA functional class (r = –0.13, p=0.54), quality of life (r = 0.00, p = 0.99).
Conclusions: CD34+ levels did not correlate with exercise capacity, functional class, quality of life and norepinephrine. Percentage of CD34+ levels did not increase during the cardiopulmonary exercise test in heart failure patients.

Abstract


Background: A previous study associated CD34+ levels with NYHA functional class in heart failure patients. The aim of this study was to correlate CD34+ levels to exercise capacity, functional class, quality of life and norepinephrine in heart failure patients.
Methods: Twenty three sedentary patients (52 ± 7 years, 78% male) answered the Minnesota Living with Heart Failure Questionnaire and rested for 20 minutes before an investigator collect a blood sample. After this, patients performed a cardiopulmonary exercise test to determine the heart rate at anaerobic and ventilatory threshold and oxygen consumption at peak effort, at anaerobic and ventilatory threshold. One other blood sample was collected during the peak effort to investigate the norepinephrine and CD34+ levels.
Results: Rest percentage of CD34+ did not show correlation with: left ventricle ejection fraction (r = 0.03, p = 0.888), peakVO2 (r = 0.32, p = 0.13), VO2 at anaerobic threshold (VO2AT) (r = 0.03, p = 0.86), VO2 at ventilatory threshold (VO2VT) (r = 0.36, p = 0.08), NYHA functional class (r = –0.2, p = 0.35), quality of life (Minnesota) (r = –0.17, p = 0.42). CD34+ did not show correlation, either, with: peakVO2 (r = 0.38, p = 0.06), VO2AT (r = 0.09, p = 0.65), VO2VT (r = 0.43, p = 0.4), NYHA functional class (r = –0.13, p=0.54), quality of life (r = 0.00, p = 0.99).
Conclusions: CD34+ levels did not correlate with exercise capacity, functional class, quality of life and norepinephrine. Percentage of CD34+ levels did not increase during the cardiopulmonary exercise test in heart failure patients.
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Keywords

exercise capacity; CD34+; quality of life; functional class; norepinephrine; stem cell

About this article
Title

Correlation between CD34+ and exercise capacity, functional class, quality of life and norepinephrine in heart failure patients

Journal

Cardiology Journal

Issue

Vol 16, No 5 (2009)

Pages

426-431

Published online

2009-07-31

Bibliographic record

Cardiol J 2009;16(5):426-431.

Keywords

exercise capacity
CD34+
quality of life
functional class
norepinephrine
stem cell

Authors

Vitor Oliveira Carvalho
Milton Artur Ruiz
Edimar Alcides Bocchi
Vagner Oliveira Carvalho
Guilherme Veiga Guimarães

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