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The relationship between cardiovascular risk estimated by use of SCORE system and intima media thickness and flow mediated dilatation in a low risk population
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Abstract
Methods: 119 people (59 men) without known cardiovascular disease and estimated by means of SCORE system risk < 5%, were included in the study. The ultrasound method was used to assess brachial artery diameter (BAd), FMD, nitroglycerin mediated dilatation (NMD) of brachial artery and IMT of common carotid. FMD × BAd and FMD/NMD indexes representing hyperemia-induced vasodilatation independent of brachial artery properties were analyzed.
Results: IMT measured was 0.52 ± 0.08 mm; FMD: 17.5 ± 7.8%; NMD: 27.0 ± 9.0%; FMD × BAd: 58.2 ± 22.4, FMD/NMD: 0.64 ± 0.19. Independent predictor for both FMD and NMD was BAd (R2 –0.31; p < 0.001; R2 –0.44; p < 0.001; respectively), for FMD × BAd index and FMD/NMD index was IMT (R2 –0.04; p = 0.02; R2 –0.04; p = 0.015) in a multivariate analysis. Risk estimated by use of the SCORE system was between 0 and 4% (median-1, 25– –75 Q: 0–2). A relationship between SCORE risk and IMT (ANOVA p < 0.001), FMD (ANOVA p < 0.001), NMD (ANOVA p < 0.001), FMD × BAd index (ANOVA p = 0.017), but not FMD/NMD index (ANOVA p = 0.27), was found.
Conclusions: The association of a simple stratifying scale (SCORE system) with indices of early vascular remodeling in a low risk population supports its clinical significance.
Abstract
Methods: 119 people (59 men) without known cardiovascular disease and estimated by means of SCORE system risk < 5%, were included in the study. The ultrasound method was used to assess brachial artery diameter (BAd), FMD, nitroglycerin mediated dilatation (NMD) of brachial artery and IMT of common carotid. FMD × BAd and FMD/NMD indexes representing hyperemia-induced vasodilatation independent of brachial artery properties were analyzed.
Results: IMT measured was 0.52 ± 0.08 mm; FMD: 17.5 ± 7.8%; NMD: 27.0 ± 9.0%; FMD × BAd: 58.2 ± 22.4, FMD/NMD: 0.64 ± 0.19. Independent predictor for both FMD and NMD was BAd (R2 –0.31; p < 0.001; R2 –0.44; p < 0.001; respectively), for FMD × BAd index and FMD/NMD index was IMT (R2 –0.04; p = 0.02; R2 –0.04; p = 0.015) in a multivariate analysis. Risk estimated by use of the SCORE system was between 0 and 4% (median-1, 25– –75 Q: 0–2). A relationship between SCORE risk and IMT (ANOVA p < 0.001), FMD (ANOVA p < 0.001), NMD (ANOVA p < 0.001), FMD × BAd index (ANOVA p = 0.017), but not FMD/NMD index (ANOVA p = 0.27), was found.
Conclusions: The association of a simple stratifying scale (SCORE system) with indices of early vascular remodeling in a low risk population supports its clinical significance.
Keywords
flow mediated dilatation; nitroglycerin mediated dilatation; intima media thickness; SCORE
About this articleTitle
The relationship between cardiovascular risk estimated by use of SCORE system and intima media thickness and flow mediated dilatation in a low risk population
Journal
Issue
Pages
407-412
Published online
2009-07-31
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630
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Bibliographic record
Cardiol J 2009;16(5):407-412.
Keywords
flow mediated dilatation
nitroglycerin mediated dilatation
intima media thickness
SCORE
Authors
Joanna Wierzbicka-Chmiel
Katarzyna Mizia-Stec
Maciej Haberka
Artur Chmiel
Magdalena Mizia
Zbigniew Gąsior
