open access

Vol 16, No 6 (2009)
Case Reports
Published online: 2009-11-19
Submitted: 2013-01-14
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Left ventricular thrombus mimicking primary cardiac tumor in a patient with primary antiphospholipid syndrome and recurrent systemic embolism

Tomás F. Cianciulli, María C. Saccheri, Jorge A. Lax, Roberto O. Neme, Juan F. Alvarez Sevillano, María E. Maiori, Sebastian Fandino Lound, Coloma E. Parisi, Horacio A. Prezioso, Luis A. Vidal
Cardiol J 2009;16(6):560-563.

open access

Vol 16, No 6 (2009)
Case Reports
Published online: 2009-11-19
Submitted: 2013-01-14

Abstract

Primary antiphospholipid syndrome (APS) is a well-defined entity characterized by spontaneous and recurrent abortion, thrombocytopenia and recurrent vascular thromboses (arterial and venous). Left ventricular thrombus mimicking primary cardiac tumor with recurrent systemic embolism has not been previously reported.
In this report we describe a 39 year-old man admitted to hospital presenting with left hemiparesis and a peripheral embolism. He had no history of thrombotic events. Transthoracic echocardiography showed a large, polypoid and mobile mass (4.0 × 1.2 cm) attached to the apex of the left ventricle, highly suggestive of primary cardiac tumor. The patient subsequently underwent open heart surgery. The histological examination showed an older thrombus and a fresh thrombus. Post-operative laboratory tests showed lupus anticoagulant activity, confirming the primary APS diagnosis. The patient initiated treatment with oral anticoagulation (INR levels between 2 and 3) and was discharged 29 days after surgery. At ten month follow-up, he was symptom-free with long-term anticoagulation therapy. No evidence of intracardiac mass recurrence on two-dimensional echocardiography was seen.
Intracardiac thrombus has been rarely reported as a complication of primary APS. Left ventricular mass mimicking primary cardiac tumor with recurrent systemic embolism has not been previously reported. Pre-operative investigations could not distinguish such a thrombus from a cardiac tumor and the diagnosis was made post-operatively.

Abstract

Primary antiphospholipid syndrome (APS) is a well-defined entity characterized by spontaneous and recurrent abortion, thrombocytopenia and recurrent vascular thromboses (arterial and venous). Left ventricular thrombus mimicking primary cardiac tumor with recurrent systemic embolism has not been previously reported.
In this report we describe a 39 year-old man admitted to hospital presenting with left hemiparesis and a peripheral embolism. He had no history of thrombotic events. Transthoracic echocardiography showed a large, polypoid and mobile mass (4.0 × 1.2 cm) attached to the apex of the left ventricle, highly suggestive of primary cardiac tumor. The patient subsequently underwent open heart surgery. The histological examination showed an older thrombus and a fresh thrombus. Post-operative laboratory tests showed lupus anticoagulant activity, confirming the primary APS diagnosis. The patient initiated treatment with oral anticoagulation (INR levels between 2 and 3) and was discharged 29 days after surgery. At ten month follow-up, he was symptom-free with long-term anticoagulation therapy. No evidence of intracardiac mass recurrence on two-dimensional echocardiography was seen.
Intracardiac thrombus has been rarely reported as a complication of primary APS. Left ventricular mass mimicking primary cardiac tumor with recurrent systemic embolism has not been previously reported. Pre-operative investigations could not distinguish such a thrombus from a cardiac tumor and the diagnosis was made post-operatively.
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Keywords

left ventricular thrombus; systemic embolism; primary antiphospholipid syndrome; primary cardiac tumor; cardiovascular surgery

About this article
Title

Left ventricular thrombus mimicking primary cardiac tumor in a patient with primary antiphospholipid syndrome and recurrent systemic embolism

Journal

Cardiology Journal

Issue

Vol 16, No 6 (2009)

Pages

560-563

Published online

2009-11-19

Bibliographic record

Cardiol J 2009;16(6):560-563.

Keywords

left ventricular thrombus
systemic embolism
primary antiphospholipid syndrome
primary cardiac tumor
cardiovascular surgery

Authors

Tomás F. Cianciulli
María C. Saccheri
Jorge A. Lax
Roberto O. Neme
Juan F. Alvarez Sevillano
María E. Maiori
Sebastian Fandino Lound
Coloma E. Parisi
Horacio A. Prezioso
Luis A. Vidal

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