open access

Vol 16, No 6 (2009)
Original articles
Published online: 2009-11-19
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Heart rate variability and heart rate turbulence in patients with chronic obstructive pulmonary disease

Huseyin Gunduz, Fahrettin Talay, Huseyin Arinc, Serhan Ozyildirim, Ramazan Akdemir, Mustafa Yolcu, Mustafa Kanat, Cihangir Uyan
Cardiol J 2009;16(6):553-559.

open access

Vol 16, No 6 (2009)
Original articles
Published online: 2009-11-19

Abstract

Background: In chronic obstructive pulmonary disease (COPD) patients, functional and structural changes of the respiratory system greatly influence cardiovascular autonomic functions. Determining autonomic balance may be important in understanding the pathophysiology of COPD and useful clinically in the treatment of COPD patients. Heart rate variability (HRV) and heart rate turbulence (HRT) are useful tools in assessing the autonomic neurovegetative function. Our aim in this study was to evaluate the HRV and HRT variables in COPD patients. Twenty five moderate to severe COPD patients and 25 healthy subjects were included in this study.
Methods: Pulmonary function tests and echocardiographic examination, arterial blood gases analysis were performed, HRV and HRT analysis were assessed from a 24-hour Holter recording.
Results: When HRV and HRT parameters were compared, COPD patients had significantly decreased sNN50 total, pNN50, SDANN, SDNN, SDNNI, rMSDD in time domain HRV parameters, and the values of the HRT onset was significantly less negative in COPD patients. Although the values of the HRT slope were lower in COPD patients, there was no significant difference between the two groups. We also found a correlation between HRT and HRV parameters.
Conclusions: In addition to HRV parameters, HRT onset was significantly different in COPD patients. In our opinion, the combination of HRV variables and HRT onset may be simple and elegant ways of evaluating cardiac autonomic functions. New investigations of HRT and HRV in COPD patients have a potential importance for improving risk stratification and therapeutic approaches, and understanding the autonomic outcomes of the disease process.

Abstract

Background: In chronic obstructive pulmonary disease (COPD) patients, functional and structural changes of the respiratory system greatly influence cardiovascular autonomic functions. Determining autonomic balance may be important in understanding the pathophysiology of COPD and useful clinically in the treatment of COPD patients. Heart rate variability (HRV) and heart rate turbulence (HRT) are useful tools in assessing the autonomic neurovegetative function. Our aim in this study was to evaluate the HRV and HRT variables in COPD patients. Twenty five moderate to severe COPD patients and 25 healthy subjects were included in this study.
Methods: Pulmonary function tests and echocardiographic examination, arterial blood gases analysis were performed, HRV and HRT analysis were assessed from a 24-hour Holter recording.
Results: When HRV and HRT parameters were compared, COPD patients had significantly decreased sNN50 total, pNN50, SDANN, SDNN, SDNNI, rMSDD in time domain HRV parameters, and the values of the HRT onset was significantly less negative in COPD patients. Although the values of the HRT slope were lower in COPD patients, there was no significant difference between the two groups. We also found a correlation between HRT and HRV parameters.
Conclusions: In addition to HRV parameters, HRT onset was significantly different in COPD patients. In our opinion, the combination of HRV variables and HRT onset may be simple and elegant ways of evaluating cardiac autonomic functions. New investigations of HRT and HRV in COPD patients have a potential importance for improving risk stratification and therapeutic approaches, and understanding the autonomic outcomes of the disease process.
Get Citation

Keywords

chronic obstructive pulmonary disease; heart rate turbulence; heart rate variability

About this article
Title

Heart rate variability and heart rate turbulence in patients with chronic obstructive pulmonary disease

Journal

Cardiology Journal

Issue

Vol 16, No 6 (2009)

Pages

553-559

Published online

2009-11-19

Bibliographic record

Cardiol J 2009;16(6):553-559.

Keywords

chronic obstructive pulmonary disease
heart rate turbulence
heart rate variability

Authors

Huseyin Gunduz
Fahrettin Talay
Huseyin Arinc
Serhan Ozyildirim
Ramazan Akdemir
Mustafa Yolcu
Mustafa Kanat
Cihangir Uyan

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