open access

Vol 17, No 1 (2010)
Original articles
Published online: 2010-01-26
Submitted: 2013-01-14
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Low adiponectin blood concentration predicts left ventricular remodeling after ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention

Katarzyna Piestrzeniewicz, Katarzyna Łuczak, Marek Maciejewski, Jarosław Drożdż
Cardiol J 2010;17(1):49-56.

open access

Vol 17, No 1 (2010)
Original articles
Published online: 2010-01-26
Submitted: 2013-01-14

Abstract

Background: Left ventricular remodeling (LVR), an increase in left ventricular end-diastolic volume index ≥ 20%, is an adverse consequence of myocardial infarction. The aim of this study was to assess the association between LVR and adiponectin, which has been shown to protect against myocardial ischemia-reperfusion injury.
Methods: In 75 patients echocardiographic examination was performed one year after ST-segment elevation myocardial infarction, successfully treated with primary percutaneous coronary intervention (pPCI). Two groups of patients were analyzed: those with LVR (n = 15) and those without LVR (n = 60).
Results: The predictors of LVR were: anterior myocardial infarction, glucose at admission, baseline C-reactive protein, adiponectin, and echocardiographic parameters: left ventricular end-diastolic and end-systolic volume indices, ejection fraction < 40% and left ventricular wall motion score index (WMSI) at discharge. On multivariable regression analysis, lower adiponectin level (OR = 0.67, 95% CI 0.49-0.91, p < 0.05) and higher WMSI (OR = 20.14, 95% CI 2.62-154.82, p < 0.01) were the only independent negative predictors of LVR. The optimal cut-off for adiponectin for predicting LVR was ≤ 4.7 mg/mL (sensitivity: 73%, specificity: 85%) and this level increased the risk of LVR 15-fold (95% CI 4.05-59.87, p = 0.0001).
Conclusions: Baseline low blood adiponectin concentration, along with WMSI, can be considered as a predictor of the LVR in male patients one year after myocardial infarction and pPCI.
(Cardiol J 2010; 17, 1: 49-56)

Abstract

Background: Left ventricular remodeling (LVR), an increase in left ventricular end-diastolic volume index ≥ 20%, is an adverse consequence of myocardial infarction. The aim of this study was to assess the association between LVR and adiponectin, which has been shown to protect against myocardial ischemia-reperfusion injury.
Methods: In 75 patients echocardiographic examination was performed one year after ST-segment elevation myocardial infarction, successfully treated with primary percutaneous coronary intervention (pPCI). Two groups of patients were analyzed: those with LVR (n = 15) and those without LVR (n = 60).
Results: The predictors of LVR were: anterior myocardial infarction, glucose at admission, baseline C-reactive protein, adiponectin, and echocardiographic parameters: left ventricular end-diastolic and end-systolic volume indices, ejection fraction < 40% and left ventricular wall motion score index (WMSI) at discharge. On multivariable regression analysis, lower adiponectin level (OR = 0.67, 95% CI 0.49-0.91, p < 0.05) and higher WMSI (OR = 20.14, 95% CI 2.62-154.82, p < 0.01) were the only independent negative predictors of LVR. The optimal cut-off for adiponectin for predicting LVR was ≤ 4.7 mg/mL (sensitivity: 73%, specificity: 85%) and this level increased the risk of LVR 15-fold (95% CI 4.05-59.87, p = 0.0001).
Conclusions: Baseline low blood adiponectin concentration, along with WMSI, can be considered as a predictor of the LVR in male patients one year after myocardial infarction and pPCI.
(Cardiol J 2010; 17, 1: 49-56)
Get Citation

Keywords

adiponectin; myocardial infarction; left ventricular remodeing

About this article
Title

Low adiponectin blood concentration predicts left ventricular remodeling after ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention

Journal

Cardiology Journal

Issue

Vol 17, No 1 (2010)

Pages

49-56

Published online

2010-01-26

Bibliographic record

Cardiol J 2010;17(1):49-56.

Keywords

adiponectin
myocardial infarction
left ventricular remodeing

Authors

Katarzyna Piestrzeniewicz
Katarzyna Łuczak
Marek Maciejewski
Jarosław Drożdż

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