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Prognostic value of cardiac troponin T elevation is independent of renal function and clinical findings in heart failure patients
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Abstract
Methods: In a prospective observational study, 152 consecutive patients from the Heart Failure Clinic of the INCMNSZ were followed for a period of 42 months. All underwent clinical evaluation, echocardiography, and determination of body composition by electric bioimpedance to identify hypervolemia. Concentrations of cTnT were quantified by immunoassay with electrochemoluminescence and ≥ 0.02 ng/mL levels were considered elevated. Also glomerular filtration rate (eGFR) was estimated using the Cockcroft-Gault equation.
Results: Elevated cTnT was significantly associated with increased all-cause mortality in the observational period even after adjusting for eGFR < 60 mL/min/1.73 m2 and clinical findings such as hypertension, functional class, loop diuretics, angiotensin converting enzyme inhibitors, pulmonary pressure and hypervolemia in Cox regression analysis with a hazard ratio of 4.58 (95% confidence interval: 1.84–11.45).
Conclusions: Heart failure patients with elevated cardiac-specific troponin T are at increased risk of death independently of the presence of chronic kidney disease.
(Cardiol J 2010; 17, 1: 42-48)
Abstract
Methods: In a prospective observational study, 152 consecutive patients from the Heart Failure Clinic of the INCMNSZ were followed for a period of 42 months. All underwent clinical evaluation, echocardiography, and determination of body composition by electric bioimpedance to identify hypervolemia. Concentrations of cTnT were quantified by immunoassay with electrochemoluminescence and ≥ 0.02 ng/mL levels were considered elevated. Also glomerular filtration rate (eGFR) was estimated using the Cockcroft-Gault equation.
Results: Elevated cTnT was significantly associated with increased all-cause mortality in the observational period even after adjusting for eGFR < 60 mL/min/1.73 m2 and clinical findings such as hypertension, functional class, loop diuretics, angiotensin converting enzyme inhibitors, pulmonary pressure and hypervolemia in Cox regression analysis with a hazard ratio of 4.58 (95% confidence interval: 1.84–11.45).
Conclusions: Heart failure patients with elevated cardiac-specific troponin T are at increased risk of death independently of the presence of chronic kidney disease.
(Cardiol J 2010; 17, 1: 42-48)
Keywords
troponin elevation; clinical findings; kidney and heart failure
About this articleTitle
Prognostic value of cardiac troponin T elevation is independent of renal function and clinical findings in heart failure patients
Journal
Issue
Pages
42-48
Published online
2010-01-26
Bibliographic record
Cardiol J 2010;17(1):42-48.
Keywords
troponin elevation
clinical findings
kidney and heart failure
Authors
Arturo Orea-Tejeda
Luis R. Sánchez-González
Lilia Castillo-Martínez
Adrian Valdespino-Trejo
Rocío N. Sánchez-Santillán
Candace Keirns-Davies
Eloisa Colín-Ramírez
Patricia Montańo-Hernández
Joel Dorantes-García