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Vol 17, No 2 (2010)
Case Reports
Published online: 2010-03-29
Submitted: 2013-01-14
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Multifactorial QT interval prolongation

Geneviève Digby, Jimmy MacHaalany, Paul Malik, Michelle Methot, Christopher S. Simpson, Damian Redfearn, Adrian Baranchuk
Cardiol J 2010;17(2):184-188.

open access

Vol 17, No 2 (2010)
Case Reports
Published online: 2010-03-29
Submitted: 2013-01-14

Abstract

Acquired long QT interval has been widely reported to be a consequence of drug therapy and electrolyte disturbances. We describe two cases of multifactorial acquired QT interval prolongation and torsades de pointes. In the first case, the drugs venlafaxine, amiodarone and domperidone may have contributed to QT interval prolongation in a patient with hypokalemia and hypomagnesaemia. In the second case, QT interval prolongation occurred in a patient taking quetiapine and citalopram, and whose use of hydrocholorothiazide and history of chronic alcohol abuse likely contributed by rendering the patient hypokalemic. These cases highlight the potential risks associated with polypharmacy and demonstrate that though torsades de pointes is an uncommon arrhythmia, the combination of multiple factors known to prolong QT interval may precipitate this life-threatening arrhythmia.
(Cardiol J 2010; 17, 2: 184-188)

Abstract

Acquired long QT interval has been widely reported to be a consequence of drug therapy and electrolyte disturbances. We describe two cases of multifactorial acquired QT interval prolongation and torsades de pointes. In the first case, the drugs venlafaxine, amiodarone and domperidone may have contributed to QT interval prolongation in a patient with hypokalemia and hypomagnesaemia. In the second case, QT interval prolongation occurred in a patient taking quetiapine and citalopram, and whose use of hydrocholorothiazide and history of chronic alcohol abuse likely contributed by rendering the patient hypokalemic. These cases highlight the potential risks associated with polypharmacy and demonstrate that though torsades de pointes is an uncommon arrhythmia, the combination of multiple factors known to prolong QT interval may precipitate this life-threatening arrhythmia.
(Cardiol J 2010; 17, 2: 184-188)

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Keywords

acquired long QT interval

About this article
Title

Multifactorial QT interval prolongation

Journal

Cardiology Journal

Issue

Vol 17, No 2 (2010)

Pages

184-188

Published online

2010-03-29

Bibliographic record

Cardiol J 2010;17(2):184-188.

Keywords

acquired long QT interval

Authors

Geneviève Digby
Jimmy MacHaalany
Paul Malik
Michelle Methot
Christopher S. Simpson
Damian Redfearn
Adrian Baranchuk

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