open access

Vol 17, No 2 (2010)
Review articles
Published online: 2010-03-29
Submitted: 2013-01-14
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Propofol infusion syndrome and Brugada syndrome electrocardiographic phenocopy

Andrés Ricardo Pérez Riera, Augusto Hiroshi Uchida, Edgardo Schapachnik, Sergio Dubner, Celso Ferreira Filho, Celso Ferreira
Cardiol J 2010;17(2):130-135.

open access

Vol 17, No 2 (2010)
Review articles
Published online: 2010-03-29
Submitted: 2013-01-14

Abstract

This anesthetic drug may cause a rare condition named propofol infusion syndrome, characterized by unexplained lactic acidosis, lipemia, rhabdomyolysis, cardiovascular collapse and Brugada-like electrocardiographic pattern or Brugada electrocardiographic phenocopy changes following high-dose propofol infusion over prolonged periods of time.
Several articles have contributed to our understanding of the cause of the syndrome, and the growing number of case reports has made it possible to identify several risk factors. Uncertainty remains as to whether a genetic susceptibility exists.
The favorable recovery profile associated with propofol offers advantages over traditional anesthetics in clinical situations in which rapid recovery is important. Propofol is a safe anesthetic agent, but propofol infusion syndrome is a rare lethal complication.
(Cardiol J 2010; 17, 2: 130-135)

Abstract

This anesthetic drug may cause a rare condition named propofol infusion syndrome, characterized by unexplained lactic acidosis, lipemia, rhabdomyolysis, cardiovascular collapse and Brugada-like electrocardiographic pattern or Brugada electrocardiographic phenocopy changes following high-dose propofol infusion over prolonged periods of time.
Several articles have contributed to our understanding of the cause of the syndrome, and the growing number of case reports has made it possible to identify several risk factors. Uncertainty remains as to whether a genetic susceptibility exists.
The favorable recovery profile associated with propofol offers advantages over traditional anesthetics in clinical situations in which rapid recovery is important. Propofol is a safe anesthetic agent, but propofol infusion syndrome is a rare lethal complication.
(Cardiol J 2010; 17, 2: 130-135)
Get Citation

Keywords

propofol mechanisms; indications; phenocopies; adverse effects; Brugada electrocardiographic-like pattern

About this article
Title

Propofol infusion syndrome and Brugada syndrome electrocardiographic phenocopy

Journal

Cardiology Journal

Issue

Vol 17, No 2 (2010)

Pages

130-135

Published online

2010-03-29

Bibliographic record

Cardiol J 2010;17(2):130-135.

Keywords

propofol mechanisms
indications
phenocopies
adverse effects
Brugada electrocardiographic-like pattern

Authors

Andrés Ricardo Pérez Riera
Augusto Hiroshi Uchida
Edgardo Schapachnik
Sergio Dubner
Celso Ferreira Filho
Celso Ferreira

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