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Can opium abuse be a risk factor for carotid stenosis in patients who are candidates for coronary artery bypass grafting?
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Abstract
Methods: All patients who were candidates for coronary artery bypass graft in Tehran Heart Center were registered and evaluated for risk factors such as diabetes mellitus, hypertension, smoking status and duration, opium abuse, involved coronary arteries and left main branch lesion > 50%, carotid stenosis ≥ 70%.
Results: A total of 1,339 patients were enrolled in the study, of whom 400 (29.9%) were female and the other 939 (70.1%) male. Female patients were omitted from analysis due to the low numbers of female opium addicts. Our study revealed that in the addicted population, the risk of diabetes and hypertension was lower than in the non-addicted group (p < 0.05 for each variable) and fasting blood sugar tended to be less in addicted ones, but the number of involved coronary arteries, left main stenosis > 50% and extent of carotid stenosis was not significantly different between the two groups.
Conclusions: Our investigations demonstrate that opium is not cardioprotective, as has been claimed by some previous studies, and does not even decelerate atherosclerosis of carotid arteries in opium-addicted patients, but more evidence is still needed to completely prove the case.
(Cardiol J 2010; 17, 3: 254-258)
Abstract
Methods: All patients who were candidates for coronary artery bypass graft in Tehran Heart Center were registered and evaluated for risk factors such as diabetes mellitus, hypertension, smoking status and duration, opium abuse, involved coronary arteries and left main branch lesion > 50%, carotid stenosis ≥ 70%.
Results: A total of 1,339 patients were enrolled in the study, of whom 400 (29.9%) were female and the other 939 (70.1%) male. Female patients were omitted from analysis due to the low numbers of female opium addicts. Our study revealed that in the addicted population, the risk of diabetes and hypertension was lower than in the non-addicted group (p < 0.05 for each variable) and fasting blood sugar tended to be less in addicted ones, but the number of involved coronary arteries, left main stenosis > 50% and extent of carotid stenosis was not significantly different between the two groups.
Conclusions: Our investigations demonstrate that opium is not cardioprotective, as has been claimed by some previous studies, and does not even decelerate atherosclerosis of carotid arteries in opium-addicted patients, but more evidence is still needed to completely prove the case.
(Cardiol J 2010; 17, 3: 254-258)
Keywords
opium abuse; carotid stenosis; atherosclerosis
About this articleTitle
Can opium abuse be a risk factor for carotid stenosis in patients who are candidates for coronary artery bypass grafting?
Journal
Issue
Pages
254-258
Published online
2010-05-28
Page views
776
Article views/downloads
1430
DOI
10.5603/cj.21374
Bibliographic record
Cardiol J 2010;17(3):254-258.
Keywords
opium abuse
carotid stenosis
atherosclerosis
Authors
Shapour Shirani
Madjid Shakiba
Maryam Soleymanzadeh
Maryam Esfandbod
