open access

Vol 17, No 3 (2010)
Original articles
Published online: 2010-05-28
Submitted: 2013-01-14
Get Citation

Can opium abuse be a risk factor for carotid stenosis in patients who are candidates for coronary artery bypass grafting?

Shapour Shirani, Madjid Shakiba, Maryam Soleymanzadeh, Maryam Esfandbod
Cardiol J 2010;17(3):254-258.

open access

Vol 17, No 3 (2010)
Original articles
Published online: 2010-05-28
Submitted: 2013-01-14

Abstract

Background: Over the centuries, opium has been the most frequent substance abused in the Middle East. There are many controversial aspects about the effects of opioids on the atherosclerosis process, which is still unclear.
Methods: All patients who were candidates for coronary artery bypass graft in Tehran Heart Center were registered and evaluated for risk factors such as diabetes mellitus, hypertension, smoking status and duration, opium abuse, involved coronary arteries and left main branch lesion > 50%, carotid stenosis ≥ 70%.
Results: A total of 1,339 patients were enrolled in the study, of whom 400 (29.9%) were female and the other 939 (70.1%) male. Female patients were omitted from analysis due to the low numbers of female opium addicts. Our study revealed that in the addicted population, the risk of diabetes and hypertension was lower than in the non-addicted group (p < 0.05 for each variable) and fasting blood sugar tended to be less in addicted ones, but the number of involved coronary arteries, left main stenosis > 50% and extent of carotid stenosis was not significantly different between the two groups.
Conclusions: Our investigations demonstrate that opium is not cardioprotective, as has been claimed by some previous studies, and does not even decelerate atherosclerosis of carotid arteries in opium-addicted patients, but more evidence is still needed to completely prove the case.
(Cardiol J 2010; 17, 3: 254-258)

Abstract

Background: Over the centuries, opium has been the most frequent substance abused in the Middle East. There are many controversial aspects about the effects of opioids on the atherosclerosis process, which is still unclear.
Methods: All patients who were candidates for coronary artery bypass graft in Tehran Heart Center were registered and evaluated for risk factors such as diabetes mellitus, hypertension, smoking status and duration, opium abuse, involved coronary arteries and left main branch lesion > 50%, carotid stenosis ≥ 70%.
Results: A total of 1,339 patients were enrolled in the study, of whom 400 (29.9%) were female and the other 939 (70.1%) male. Female patients were omitted from analysis due to the low numbers of female opium addicts. Our study revealed that in the addicted population, the risk of diabetes and hypertension was lower than in the non-addicted group (p < 0.05 for each variable) and fasting blood sugar tended to be less in addicted ones, but the number of involved coronary arteries, left main stenosis > 50% and extent of carotid stenosis was not significantly different between the two groups.
Conclusions: Our investigations demonstrate that opium is not cardioprotective, as has been claimed by some previous studies, and does not even decelerate atherosclerosis of carotid arteries in opium-addicted patients, but more evidence is still needed to completely prove the case.
(Cardiol J 2010; 17, 3: 254-258)
Get Citation

Keywords

opium abuse; carotid stenosis; atherosclerosis

About this article
Title

Can opium abuse be a risk factor for carotid stenosis in patients who are candidates for coronary artery bypass grafting?

Journal

Cardiology Journal

Issue

Vol 17, No 3 (2010)

Pages

254-258

Published online

2010-05-28

Bibliographic record

Cardiol J 2010;17(3):254-258.

Keywords

opium abuse
carotid stenosis
atherosclerosis

Authors

Shapour Shirani
Madjid Shakiba
Maryam Soleymanzadeh
Maryam Esfandbod

Important: This website uses cookies.tanya dokter More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk, Poland
tel.:+48 58 320 94 94, fax:+48 58 320 94 60, e-mail: viamedica@viamedica.pl