Vol 17, No 4 (2010)
Original articles
Published online: 2010-07-27
Forward stroke volume is predictor of perioperative course in patients with mitral regurgitation undergoing mitral valve replacement
Cardiol J 2010;17(4):386-389.
Abstract
Background: Decreased left ventricle ejection fraction (LVEF) is a predictor of poor late
outcome in patients with mitral regurgitation (MR). The relationship between pre-operative
forward stroke volume (SV) and right heart parameters and perioperative outcome in patients
with MR has been little studied.
Methods: Forty patients with severe organic MR, unsuitable for mitral valve repair, who underwent mitral valve replacement (MVR) were included in the study (50% men, average age 61 ± 9 years). Exclusion criteria were: aortic valve disease, coronary artery disease, rethoracotomy, stroke, infection or significant perioperative bleeding. Pre-operative detailed echocardiographic examination was performed. The end-point was post-operative prolonged intensive care unit (ICU) stay of more than three days because of the need for inotropic support.
Results: Pre-operative NYHA class was 2.6 ± 0.4, mean right ventricular end-diastolic diameter (RVEDD) was 28.7 ± 4 mm, TAPSE was 20 ± 4 mm, mean right ventricular systolic pressure (RVSP) was 38 ± 13 mm Hg, left ventricular end-systolic diameter was 43.5 ± 11 mm, left ventricular end-diastolic diameter was 60 ± 11 mm, left ventricular enddiastolic volume (Simpson) was 155 ± 47 mL, LVEF was 55 ± 11%, mean regurgitation fraction was 58% and forward SV (measured by Doppler) was 35 ± ± 11 mL. All patients survived the operation. Mean ICU stay was 3.2 ± 2.9 days (range 1-10 days), mean TISS-28 was 623 ± 293 and mean NEMS 151 ± 85. By univariate analysis, ICU stay was significantly longer in patients in higher pre-operative NYHA (p = 0.04), lower LVEF (p = 0.01), lower forward SV (p = 0.001) higher RF (p = 0.01), pre-operative right ventricular dilatation (p = 0.04), higher RVSP (p = 0.006) and right ventricular dysfunction (p = 0.04). By multivariate analysis, forward SV (p = 0.002, b = –0.45) and RVEDD (p = 0.02, b = 0.31) were independent predictors for prolonged ICU stay.
Conclusions: Pre-operative forward stroke volume and right ventricle size are predictors of the perioperative hemodynamic status in patients with mitral regurgitation undergoing MVR.
(Cardiol J 2010; 17, 4: 386-389)
Methods: Forty patients with severe organic MR, unsuitable for mitral valve repair, who underwent mitral valve replacement (MVR) were included in the study (50% men, average age 61 ± 9 years). Exclusion criteria were: aortic valve disease, coronary artery disease, rethoracotomy, stroke, infection or significant perioperative bleeding. Pre-operative detailed echocardiographic examination was performed. The end-point was post-operative prolonged intensive care unit (ICU) stay of more than three days because of the need for inotropic support.
Results: Pre-operative NYHA class was 2.6 ± 0.4, mean right ventricular end-diastolic diameter (RVEDD) was 28.7 ± 4 mm, TAPSE was 20 ± 4 mm, mean right ventricular systolic pressure (RVSP) was 38 ± 13 mm Hg, left ventricular end-systolic diameter was 43.5 ± 11 mm, left ventricular end-diastolic diameter was 60 ± 11 mm, left ventricular enddiastolic volume (Simpson) was 155 ± 47 mL, LVEF was 55 ± 11%, mean regurgitation fraction was 58% and forward SV (measured by Doppler) was 35 ± ± 11 mL. All patients survived the operation. Mean ICU stay was 3.2 ± 2.9 days (range 1-10 days), mean TISS-28 was 623 ± 293 and mean NEMS 151 ± 85. By univariate analysis, ICU stay was significantly longer in patients in higher pre-operative NYHA (p = 0.04), lower LVEF (p = 0.01), lower forward SV (p = 0.001) higher RF (p = 0.01), pre-operative right ventricular dilatation (p = 0.04), higher RVSP (p = 0.006) and right ventricular dysfunction (p = 0.04). By multivariate analysis, forward SV (p = 0.002, b = –0.45) and RVEDD (p = 0.02, b = 0.31) were independent predictors for prolonged ICU stay.
Conclusions: Pre-operative forward stroke volume and right ventricle size are predictors of the perioperative hemodynamic status in patients with mitral regurgitation undergoing MVR.
(Cardiol J 2010; 17, 4: 386-389)
Keywords: mitral regurgitationstroke volumeright ventriclemitral valve replacementechocardiographyprognosis
