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The effect of early and intensive statin therapy on ventricular premature beat or non-sustained ventricular tachycardia in patients with acute coronary syndrome
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Abstract
Methods: Some 586 patients with acute coronary syndrome were randomly divided into two groups: Group A (with conventional statin therapy, to receive 10 mg/day atorvastatin, n = 289) and Group B (given early and intensive statin therapy, 60 mg immediately and 40 mg/day atorvastatin, n = 297). The frequency of ventricular premature beat and NSVT was recorded via Holter monitoring after hospitalization (24 h and 72 h). Results: Seventy seven (11.8%) patients had NSVT. When compared to patients with no documented NSVT, patients with NSVT were older and more frequently had myocardial infarction in their history, diabetes mellitus, atrial fibrillation and an ejection fraction < 40%. Ventricular premature beats decreased significantly in the early and aggressive treatment group (24 h, p < 0.01; 72 h, p < 0.001). A significant reduction in NSVT was seen in the early and aggressive treatment group (24 h, p < 0.01; 72 h, p < 0.001). There were no side effects observed in either group.
Conclusions: Early and intensive lipid-lowering treatment can clearly decrease ventricular premature beats and NSVT.
(Cardiol J 2010; 17, 4: 381-385)
Abstract
Methods: Some 586 patients with acute coronary syndrome were randomly divided into two groups: Group A (with conventional statin therapy, to receive 10 mg/day atorvastatin, n = 289) and Group B (given early and intensive statin therapy, 60 mg immediately and 40 mg/day atorvastatin, n = 297). The frequency of ventricular premature beat and NSVT was recorded via Holter monitoring after hospitalization (24 h and 72 h). Results: Seventy seven (11.8%) patients had NSVT. When compared to patients with no documented NSVT, patients with NSVT were older and more frequently had myocardial infarction in their history, diabetes mellitus, atrial fibrillation and an ejection fraction < 40%. Ventricular premature beats decreased significantly in the early and aggressive treatment group (24 h, p < 0.01; 72 h, p < 0.001). A significant reduction in NSVT was seen in the early and aggressive treatment group (24 h, p < 0.01; 72 h, p < 0.001). There were no side effects observed in either group.
Conclusions: Early and intensive lipid-lowering treatment can clearly decrease ventricular premature beats and NSVT.
(Cardiol J 2010; 17, 4: 381-385)
Keywords
acute coronary syndrome; atorvastatin; ventricular premature beat; non-sustained ventricular tachycardia
About this articleTitle
The effect of early and intensive statin therapy on ventricular premature beat or non-sustained ventricular tachycardia in patients with acute coronary syndrome
Journal
Issue
Pages
381-385
Published online
2010-07-27
Page views
689
Article views/downloads
1338
DOI
10.5603/cj.21357
Bibliographic record
Cardiol J 2010;17(4):381-385.
Keywords
acute coronary syndrome
atorvastatin
ventricular premature beat
non-sustained ventricular tachycardia
Authors
Xian-zhi He
Sheng-hua Zhou
Xin-hong Wan
Hai-yu Wang
Qing-hua Zhong
Jian-fang Xue
