open access

Vol 17, No 4 (2010)
Review articles
Published online: 2010-07-27
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Clinical implication of gastrointestinal bleeding in degenerative aortic stenosis: An update

Wojciech Gola, Małgorzata Lelonek
Cardiol J 2010;17(4):330-334.

open access

Vol 17, No 4 (2010)
Review articles
Published online: 2010-07-27

Abstract

Gastrointestinal (GI) bleeding due to colonic angiodysplasias can be associated with calcifying aortic stenosis (AS). GI angiodysplasias and AS are defined as chronic degenerative disorders, and the prevalence of both diseases increases with age. Moreover, degenerative AS is associated with increased destruction of high molecular weight multimers of von Willebrand factor which can promote bleeding from intestinal angiodysplasias. The coincidence of gastrointestinal bleeding angiodysplasias and AS has been known for many years as Heyde’s syndrome. Aortic valve replacement is the first line therapy for advanced stage AS-patients, but can also be an effective treatment for co-existent bleeding angiodysplasias and acquired von Willebrand disease. In this study, we tried to collect as well as systemized data about the etiopathogenesis of AS coagulation abnormalities and diagnostic, clinical and therapeutic implications of AS-patient with GI angiodysplasias.
(Cardiol J 2010; 17, 4: 330-334)

Abstract

Gastrointestinal (GI) bleeding due to colonic angiodysplasias can be associated with calcifying aortic stenosis (AS). GI angiodysplasias and AS are defined as chronic degenerative disorders, and the prevalence of both diseases increases with age. Moreover, degenerative AS is associated with increased destruction of high molecular weight multimers of von Willebrand factor which can promote bleeding from intestinal angiodysplasias. The coincidence of gastrointestinal bleeding angiodysplasias and AS has been known for many years as Heyde’s syndrome. Aortic valve replacement is the first line therapy for advanced stage AS-patients, but can also be an effective treatment for co-existent bleeding angiodysplasias and acquired von Willebrand disease. In this study, we tried to collect as well as systemized data about the etiopathogenesis of AS coagulation abnormalities and diagnostic, clinical and therapeutic implications of AS-patient with GI angiodysplasias.
(Cardiol J 2010; 17, 4: 330-334)
Get Citation

Keywords

aortic stenosis; angiodysplasia; von Willebrand disease; Heyde’s syndrome

About this article
Title

Clinical implication of gastrointestinal bleeding in degenerative aortic stenosis: An update

Journal

Cardiology Journal

Issue

Vol 17, No 4 (2010)

Pages

330-334

Published online

2010-07-27

Bibliographic record

Cardiol J 2010;17(4):330-334.

Keywords

aortic stenosis
angiodysplasia
von Willebrand disease
Heyde’s syndrome

Authors

Wojciech Gola
Małgorzata Lelonek

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