open access

Vol 17, No 5 (2010)
Original articles
Published online: 2010-09-23
Submitted: 2013-01-14
Get Citation

Impairment of the left ventricular systolic and diastolic function in patients with non-alcoholic fatty liver disease

Hakan Fotbolcu, Tolga Yakar, Dursun Duman, Tansu Karaahmet, Kursat Tigen, Cihan Cevik, Unal Kurtoglu, Ismet Dindar
Cardiol J 2010;17(5):457-463.

open access

Vol 17, No 5 (2010)
Original articles
Published online: 2010-09-23
Submitted: 2013-01-14

Abstract


Background: Non-alcoholic fatty liver disease (NAFLD) is considered the liver component of the metabolic syndrome. We investigated the diastolic and systolic functional parameters of patients with NAFLD and the impact of metabolic syndrome on these parameters.
Methods: Thirty-five non-diabetic, normotensive NAFLD patients, and 30 controls, were included in this study. Each patient underwent transthoracic conventional and tissue Doppler echocardiography (TDI) for the assessment of left ventricular (LV) diastolic and systolic function. Study patients were also evaluated with 24-hour ambulatory blood pressure monitoring.
Results: NAFLD patients had higher blood pressures, increased body mass indices, and more insulin resistance than controls. TDI early diastolic velocity (E’ on TDI) values were lower in NAFLD patients than the controls (11.1 ± 2.1 vs 15.3 ± 2.7; p < 0.001). TDI systolic velocity (S’ on TDI) values were lower in NAFLD patients than the controls (9.34 ± 1.79 vs 10.6 ± 1.52; p = 0.004). E’ on TDI and S’ on TDI values were moderately correlated with night-systolic blood pressure, night-diastolic blood pressure, and night-mean blood pressure in NAFLD patients.
Conclusions: Patients with NAFLD have impaired LV systolic and diastolic function even in the absence of morbid obesity, hypertension, or diabetes. (Cardiol J 2010; 17, 5: 457-463)

Abstract


Background: Non-alcoholic fatty liver disease (NAFLD) is considered the liver component of the metabolic syndrome. We investigated the diastolic and systolic functional parameters of patients with NAFLD and the impact of metabolic syndrome on these parameters.
Methods: Thirty-five non-diabetic, normotensive NAFLD patients, and 30 controls, were included in this study. Each patient underwent transthoracic conventional and tissue Doppler echocardiography (TDI) for the assessment of left ventricular (LV) diastolic and systolic function. Study patients were also evaluated with 24-hour ambulatory blood pressure monitoring.
Results: NAFLD patients had higher blood pressures, increased body mass indices, and more insulin resistance than controls. TDI early diastolic velocity (E’ on TDI) values were lower in NAFLD patients than the controls (11.1 ± 2.1 vs 15.3 ± 2.7; p < 0.001). TDI systolic velocity (S’ on TDI) values were lower in NAFLD patients than the controls (9.34 ± 1.79 vs 10.6 ± 1.52; p = 0.004). E’ on TDI and S’ on TDI values were moderately correlated with night-systolic blood pressure, night-diastolic blood pressure, and night-mean blood pressure in NAFLD patients.
Conclusions: Patients with NAFLD have impaired LV systolic and diastolic function even in the absence of morbid obesity, hypertension, or diabetes. (Cardiol J 2010; 17, 5: 457-463)
Get Citation

Keywords

left ventricular function; non-alcoholic fatty liver disease; echocardiography

About this article
Title

Impairment of the left ventricular systolic and diastolic function in patients with non-alcoholic fatty liver disease

Journal

Cardiology Journal

Issue

Vol 17, No 5 (2010)

Pages

457-463

Published online

2010-09-23

Bibliographic record

Cardiol J 2010;17(5):457-463.

Keywords

left ventricular function
non-alcoholic fatty liver disease
echocardiography

Authors

Hakan Fotbolcu
Tolga Yakar
Dursun Duman
Tansu Karaahmet
Kursat Tigen
Cihan Cevik
Unal Kurtoglu
Ismet Dindar

Important: This website uses cookies.tanya dokter More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk, Poland
tel.:+48 58 320 94 94, fax:+48 58 320 94 60, e-mail: viamedica@viamedica.pl