open access

Vol 17, No 6 (2010)
Original articles
Published online: 2010-12-08
Submitted: 2013-01-14
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Effect of L-arginine or L-citrulline oral supplementation on blood pressure and right ventricular function in heart failure patients with preserved ejection fraction

Juan José Orozco-Gutiérrez, Lilia Castillo-Martínez, Arturo Orea-Tejeda, Oscar Vázquez-Díaz, Adrián Valdespino-Trejo, René Narváez-David, Candace Keirns-Davis, Olín Carrasco-Ortiz, Adolfo Navarro-Navarro, Rocío Sánchez-Santillán
Cardiol J 2010;17(6):612-618.

open access

Vol 17, No 6 (2010)
Original articles
Published online: 2010-12-08
Submitted: 2013-01-14

Abstract


Background: The effect of L-arginine and L-citrulline on blood pressure and right ventricular function in heart failure patients with preserved ejection fraction (HFpEF) is unknown. We have therefore evaluated, in a randomized clinical trial, the effect of these aminoacids in chronic outstanding and stable patients with HFpEF.
Methods and results: All patients underwent an echocardiogram and radioisotopic ventriculography rest/exercise, and were randomized in a consecutive manner to the L-arginine group (n = 15; 8 g/day); and the citrulline malate group (n = 15; 3 g/day). The duration of follow-up was two months. The principal echocardiographic finding was a statistically significant decrease in pulmonary artery pressure in the L-arginine (56.3 &#177; 10 vs 44 &#177; 16.5 mm Hg, p < 0.05) and the citrulline (56.67 &#177; 7.96 vs 47.67 &#177; 8.59 mm Hg, p < 0.05) groups. Duration on treadmill and right ventricular ejection fraction post exercise increased, while diastolic and systolic artery pressure decreased significantly in both groups. There were no other statistically significant differences between the groups.
Conclusions: Administration of L-arginine and citrulline to patients with HFpEF improved right ventricular function by increasing right ventricular ejection fraction, and probably decreasing systolic pulmonary artery pressure. (Cardiol J 2010; 17, 6: 612-618)

Abstract


Background: The effect of L-arginine and L-citrulline on blood pressure and right ventricular function in heart failure patients with preserved ejection fraction (HFpEF) is unknown. We have therefore evaluated, in a randomized clinical trial, the effect of these aminoacids in chronic outstanding and stable patients with HFpEF.
Methods and results: All patients underwent an echocardiogram and radioisotopic ventriculography rest/exercise, and were randomized in a consecutive manner to the L-arginine group (n = 15; 8 g/day); and the citrulline malate group (n = 15; 3 g/day). The duration of follow-up was two months. The principal echocardiographic finding was a statistically significant decrease in pulmonary artery pressure in the L-arginine (56.3 &#177; 10 vs 44 &#177; 16.5 mm Hg, p < 0.05) and the citrulline (56.67 &#177; 7.96 vs 47.67 &#177; 8.59 mm Hg, p < 0.05) groups. Duration on treadmill and right ventricular ejection fraction post exercise increased, while diastolic and systolic artery pressure decreased significantly in both groups. There were no other statistically significant differences between the groups.
Conclusions: Administration of L-arginine and citrulline to patients with HFpEF improved right ventricular function by increasing right ventricular ejection fraction, and probably decreasing systolic pulmonary artery pressure. (Cardiol J 2010; 17, 6: 612-618)
Get Citation

Keywords

L-arginine; citrulline; heart failure; blood pressure; right ventricle

About this article
Title

Effect of L-arginine or L-citrulline oral supplementation on blood pressure and right ventricular function in heart failure patients with preserved ejection fraction

Journal

Cardiology Journal

Issue

Vol 17, No 6 (2010)

Pages

612-618

Published online

2010-12-08

Bibliographic record

Cardiol J 2010;17(6):612-618.

Keywords

L-arginine
citrulline
heart failure
blood pressure
right ventricle

Authors

Juan José Orozco-Gutiérrez
Lilia Castillo-Martínez
Arturo Orea-Tejeda
Oscar Vázquez-Díaz
Adrián Valdespino-Trejo
René Narváez-David
Candace Keirns-Davis
Olín Carrasco-Ortiz
Adolfo Navarro-Navarro
Rocío Sánchez-Santillán

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