open access

Vol 18, No 1 (2011)
Original articles
Published online: 2011-02-08
Submitted: 2013-01-14
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Plasma homocysteine and the severity of heart failure in patients with previous myocardial infarction

Lucia Agoston-Coldea, Teodora Mocan, Marc Gatfosse, Silvia Lupu, Dan L. Dumitrascu
Cardiol J 2011;18(1):55-62.

open access

Vol 18, No 1 (2011)
Original articles
Published online: 2011-02-08
Submitted: 2013-01-14

Abstract


Background: Homocysteine is considered to be a risk factor, or an indicator of risk, for the development of cardiovascular disease. Little data is available on its significance in patients with previous myocardial infarction. The aim of our study was to assess the plasma level of homocysteine and its relationship with the severity of heart failure in patients with chronic myocardial infarction.
Methods: We studied 144 patients with previous myocardial infarction. Patients were divided into two groups according to the presence or absence of heart failure, as certified by clinical evidence of heart failure and by echocardiographic criteria for left ventricular systolic dysfunction.
Results: Of the patients with prior myocardial infarction (144; 63.6 ± 9.6 years) included in the study, 65 had heart failure. The mean level of homocysteine was significantly higher in the heart failure group (18.9 mmol/L) than in the non-heart failure group (14.1 mmol/L; p ≤ 0.001). Our study demonstrated that there is a statistically significant correlation between homocysteine plasma levels and the severity of heart failure in patients with prior myocardial infarction. Homocysteine levels have proved to become higher with NYHA class progression. A significant cross-sectional correlation has been assessed between homocysteine and tissue Doppler echocardiography parameters.
Conclusions: Increased plasma homocysteine levels independently correlate with the severity of heart failure in patients with chronic myocardial infarction. We suggest that homocysteine can be used in clinical practice as a valuable heart failure risk marker in patients with chronic myocardial infarction. (Cardiol J 2011; 18, 1: 55-62)

Abstract


Background: Homocysteine is considered to be a risk factor, or an indicator of risk, for the development of cardiovascular disease. Little data is available on its significance in patients with previous myocardial infarction. The aim of our study was to assess the plasma level of homocysteine and its relationship with the severity of heart failure in patients with chronic myocardial infarction.
Methods: We studied 144 patients with previous myocardial infarction. Patients were divided into two groups according to the presence or absence of heart failure, as certified by clinical evidence of heart failure and by echocardiographic criteria for left ventricular systolic dysfunction.
Results: Of the patients with prior myocardial infarction (144; 63.6 ± 9.6 years) included in the study, 65 had heart failure. The mean level of homocysteine was significantly higher in the heart failure group (18.9 mmol/L) than in the non-heart failure group (14.1 mmol/L; p ≤ 0.001). Our study demonstrated that there is a statistically significant correlation between homocysteine plasma levels and the severity of heart failure in patients with prior myocardial infarction. Homocysteine levels have proved to become higher with NYHA class progression. A significant cross-sectional correlation has been assessed between homocysteine and tissue Doppler echocardiography parameters.
Conclusions: Increased plasma homocysteine levels independently correlate with the severity of heart failure in patients with chronic myocardial infarction. We suggest that homocysteine can be used in clinical practice as a valuable heart failure risk marker in patients with chronic myocardial infarction. (Cardiol J 2011; 18, 1: 55-62)
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Keywords

homocysteine; myocardial infarction; left ventricular dysfunction; heart failure

About this article
Title

Plasma homocysteine and the severity of heart failure in patients with previous myocardial infarction

Journal

Cardiology Journal

Issue

Vol 18, No 1 (2011)

Pages

55-62

Published online

2011-02-08

Bibliographic record

Cardiol J 2011;18(1):55-62.

Keywords

homocysteine
myocardial infarction
left ventricular dysfunction
heart failure

Authors

Lucia Agoston-Coldea
Teodora Mocan
Marc Gatfosse
Silvia Lupu
Dan L. Dumitrascu

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