Vol 18, No 3 (2011)
Original articles
Published online: 2011-06-09

open access

Page views 732
Article views/downloads 1032
Get Citation

Connect on Social Media

Connect on Social Media

Low admission triglyceride and mortality in acute coronary syndrome patients

Owais A. Khawaja, Hazem Hatahet, Joao Cavalcante, Sanjaya Khanal, Mouaz H. Al-Mallah
Cardiol J 2011;18(3):297-303.

Abstract

Background: The relationship between admission triglyceride (TG) levels and long-term outcomes has not been established in patients with acute coronary syndrome. We tested the hypothesis that patients who develop non-ST segment elevation myocardial infarction (NSTEMI) despite low TG have a worse cardiovascular outcome in the long term.
Methods: Patients admitted with NSTEMI between 1 January 1997 and 31 December 2000 and with fasting lipid profiles measured within 24 hours of admission were included for analysis. Baseline characteristics and three-year all-cause mortality were compared between the patients with TG above and below the median. Multivariate analysis was used to determine the predictors of all-cause mortality and adjusted survival was analyzed using the Cox proportional hazard model.
Results: Of 517 patients, 395 had TG £ 200 mg/dL and 124 had TG > 200 mg/dL. Patients with low TG were more often Caucasian, with no significant differences in gender or severity of coronary artery disease between the two groups. There was a trend for increased all-cause mortality at six months (9% vs 3%, p = 0.045) and three years (13.4% vs 5.6%, p = 0.016) in patients with low TG. In multivariate analysis, low TG level at admission was an independent predictor of increased mortality at three years (adjusted OR 2.5, 95% CI = 1.04–5.9, p = 0.04).
Conclusions: In our cohort, lower TG at admission is associated with increased three-year mortality in patients with NSTEMI. Whether this is a result of current therapy, or a marker for worse baseline characteristics, needs to be studied further. (Cardiol J 2011; 18, 3: 297–303)

Article available in PDF format

View PDF Download PDF file