open access

Vol 18, No 4 (2011)
Review articles
Published online: 2011-07-15
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Serum autoantibodies against human oxidized low-density lipoproteins are inversely associated with severity of coronary stenotic lesions calculated by Gensini score

Jingjin Che, Guangping Li, Weiding Wang, Qiang Li, Hongtao Liu, Kangyin Chen, Tong Liu
Cardiol J 2011;18(4):364-370.

open access

Vol 18, No 4 (2011)
Review articles
Published online: 2011-07-15

Abstract

Background: The relationship between autoantibodies against human oxidized low-density lipoprotein (anti-oxLDL) and the progression of atherosclerotic diseases is unclear. This study aimed to investigate the association between serum anti-oxLDL titers and the severity and extent of coronary stenotic lesions.
Methods: We measured the titers of IgG anti-oxLDL by enzyme-linked immunosorbent assay (ELISA) in 154 consecutive patients undergoing coronary angiography for suspected coronary heart disease (CHD). The severity and extent of coronary stenotic lesions were evaluated on coronary angiography findings by Gensini score.
Results: The anti-oxLDL titers were significantly lower in 117 patients with CHD than those in 37 controls (p < 0.01). The serum anti-oxLDL titers were significantly correlated to serum levels of globulin (r = 0.405), conjugated bilirubin (r = 0.280), high-density lipoprotein (HDL) cholesterol (r = 0.238), homeostatic model assessment for insulin resistance (HOMA-IR) (r = –0.267), high sensitivity C-reactive protein (hs-CRP) (r = –0.230), triglyceride (r = –0.207), advanced glycation end products (AGEs) (r = –0.200), and malondialdehyde (r = –0.165). However, only HDL cholesterol and AGEs remained independent predictors of the anti-oxLDL titers after adjusting for confounders. Multivariate regression analysis showed that the anti-oxLDL titers, as well as serum levels of hs-CRP, fasting glucose, and albumin, were significantly associated with Gensini scores.
Conclusions: Titers of anti-oxLDL are inversely associated with complicated proatherogenic metabolic risk factors, and the severity of coronary stenotic lesions calculated by Gensini scores, supporting a protective role for anti-oxLDL against the progression of atherosclerosis. (Cardiol J 2011; 18, 4: 364–370)

Abstract

Background: The relationship between autoantibodies against human oxidized low-density lipoprotein (anti-oxLDL) and the progression of atherosclerotic diseases is unclear. This study aimed to investigate the association between serum anti-oxLDL titers and the severity and extent of coronary stenotic lesions.
Methods: We measured the titers of IgG anti-oxLDL by enzyme-linked immunosorbent assay (ELISA) in 154 consecutive patients undergoing coronary angiography for suspected coronary heart disease (CHD). The severity and extent of coronary stenotic lesions were evaluated on coronary angiography findings by Gensini score.
Results: The anti-oxLDL titers were significantly lower in 117 patients with CHD than those in 37 controls (p < 0.01). The serum anti-oxLDL titers were significantly correlated to serum levels of globulin (r = 0.405), conjugated bilirubin (r = 0.280), high-density lipoprotein (HDL) cholesterol (r = 0.238), homeostatic model assessment for insulin resistance (HOMA-IR) (r = –0.267), high sensitivity C-reactive protein (hs-CRP) (r = –0.230), triglyceride (r = –0.207), advanced glycation end products (AGEs) (r = –0.200), and malondialdehyde (r = –0.165). However, only HDL cholesterol and AGEs remained independent predictors of the anti-oxLDL titers after adjusting for confounders. Multivariate regression analysis showed that the anti-oxLDL titers, as well as serum levels of hs-CRP, fasting glucose, and albumin, were significantly associated with Gensini scores.
Conclusions: Titers of anti-oxLDL are inversely associated with complicated proatherogenic metabolic risk factors, and the severity of coronary stenotic lesions calculated by Gensini scores, supporting a protective role for anti-oxLDL against the progression of atherosclerosis. (Cardiol J 2011; 18, 4: 364–370)
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Keywords

autoantibodies against human oxidized low-density lipoprotein; Gensini score; coronary heart disease

About this article
Title

Serum autoantibodies against human oxidized low-density lipoproteins are inversely associated with severity of coronary stenotic lesions calculated by Gensini score

Journal

Cardiology Journal

Issue

Vol 18, No 4 (2011)

Pages

364-370

Published online

2011-07-15

Bibliographic record

Cardiol J 2011;18(4):364-370.

Keywords

autoantibodies against human oxidized low-density lipoprotein
Gensini score
coronary heart disease

Authors

Jingjin Che
Guangping Li
Weiding Wang
Qiang Li
Hongtao Liu
Kangyin Chen
Tong Liu

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