Vol 18, No 6 (2011)
How to do
Published online: 2011-11-23
Post percutaneous coronary intervention antiplatelet therapy: Current perceptions, prospects and perplexity
Cardiol J 2011;18(6):712-717.
Abstract
Dual antiplatelet therapy (DAT) has become standard care for patients undergoing percutaneous
coronary intervention (PCI). Following balloon injury and stent placement, the intima at
the site is distressed, resulting in the activation of coagulation cascade and platelets. In the
case of bare metal stents (BMS), it takes six to eight weeks for the stent surface to be covered
with neointima. However, in the case of a drug-eluting stent (DES), the process of healing is
delayed and neointima may not form for months or even years. To prevent the formation of
platelet thrombi, dual antiplatelet therapy is given as a combination of aspirin and clopidogrel
for three months in a case of BMS and for a minimum of one year in a case of DES.
A prolonged duration of therapy is often required for a subset of patients who are highly prone to
thrombus formation. During most non-cardiac surgeries, dual antiplatelet therapy should be
continued if bleeding can be directly controlled and excessive bleeding will have no adverse
effect on the outcome of surgery. Prasugrel, another thienopyridine, is more potent and faster
acting than clopidogrel, and is therefore of great value in cases of acute coronary syndrome
during PCI, particularly in diabetics. Triple drug therapy, by adding cilastozol, is reserved for
some selected thrombotic lesions. Ticagrelor and cangrelor are two new antiplatelet agents
undergoing various clinical trials. (Cardiol J 2011; 18, 6: 712–717)
Keywords: percutaneous coronary interventiondual antiplatelet therapyrestenosis