Tom 8, Nr 5 (2023)
Obrazy w medycynie
Opublikowany online: 2023-08-17

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Rare case of recurrent myofibroblastoma in a female patient

Stanisław Ciechanowicz1, Piotr Kupidłowski1, Mateusz Wichtowski1
Biuletyn Polskiego Towarzystwa Onkologicznego Nowotwory 2023;8(5):391.

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Obrazy w onkologii / Pictures in oncology

Biuletyn Polskiego
Towarzystwa Onkologicznego
NOWOTWORY

2023, tom 8, nr 5, 391

© Polskie Towarzystwo Onkologiczne

ISSN: 2543–5248, e-ISSN: 2543–8077

www.nowotwory.edu.pl

Rare case of recurrent myofibroblastoma in a female patient

Stanisław Ciechanowicz Piotr Kupidłowski Mateusz Wichtowski
Surgical Oncology Clinic, Poznan University of Medical Sciences, Poznan, Poland

Jak cytować / How to cite:

Ciechanowicz S, Kupidłowski P, Wichtowski M. Rare case of recurrent myofibroblastoma in a female patient. NOWOTWORY J Oncol 2023; 73: 323.

A 61-year-old female patient presented with a painless lump located in the right breast. In 2015 she was diagnosed with mammary-type myofibroblastoma (MFB) in the right breast and underwent a resection. In 2016 there was a unilateral relapse and the second tumorectomy was performed. The patient underwent core needle biopsy, which indicated a non-epithelial spindle cell lesion with immunohistochemistry results CD34+;S100–; p63–; CKPAN–; ER–. On the MRI there was a lobular tumour (37 x 42 x 57 mm) with 2 satellite lesions. Due to the size of the tumour and previous breast surgeries, a nipple sparing mastectomy with reconstruction was performed. Histopathology confirmed MFB (fig. 1, fig. 2). MFB is a rare benign spindle cell tumour of the breast. Due to its rare incidence, no risk factors or genetic predispositions are identified [1]. As MFB is well encapsulated, the treatment of choice is surgery without further adjuvant therapy. Only one relapse of MFB has been reported in the literature so far [2]. There is little data concerning recurrence of MFB [2], therefore careful observation and documentation of recurrent MFBs could prove beneficial in studying the nature of MFB and treating patients.

Figure 1. Microscopic display of hematoxylin and eosin-stained section of classic myofibroblastoma
Figure 2. Spindle shaped, slender, blend and uniform cells closely packed in short fascicles intermixed with hyalinised, thick collagen bundles

References

  1. Magro G. Mammary myofibroblastoma: a tumor with a wide morphologic spectrum. Arch Pathol Lab Med. 2008; 132(11): 1813–1820, doi: 10.5858/132.11.1813, indexed in Pubmed: 18976021.
  2. Scardina L, Franceschini G, Biondi E, et al. Myofibroblastoma of the breast: two case reports and literature review. J Surg Case Rep. 2021; 2021(4): rjab133, doi: 10.1093/jscr/rjab133, indexed in Pubmed: 33927867.



Biuletyn Polskiego Towarzystwa Onkologicznego Nowotwory