dostęp otwarty
Retrospective analysis of the treatment of BRCA1 and BRCA2 mutation carriers – the experience of a single-center tertiary institution
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Afiliacje- Department of Oncological Physiotherapy, Medical University of Lodz, Lodz, Poland
- Department of Surgical Oncology and Breast Diseases, Polish Mother’s Memorial Hospital – Research Institute, Lodz, Poland
- Breast Unit Cancer Center, Copernicus Memorial Hospital, Lodz, Poland
dostęp otwarty
Streszczenie
Introduction.Breast cancer gene 1 and 2 (BRCA1/2) mutation carriers are at a higher risk of developing breast cancer. There are several established risk-reducing therapies. Our study aimed to characterize the BRCA1/2 mutation carriers, and to evaluate the implemented treatment methods.
Material and methods.A retrospective analysis of clinical records of 96 female patients hospitalized from October 2019 to December 2022 in the Breast Cancer Unit in Lodz, Poland.
Results.Out of 85 BRCA1 and 11 BRCA2 mutation carriers, 96.88% received nipple-sparing or skin-sparing, unilateral or bilateral risk-reducing mastectomies. Out of all the patients, 36 developed 38 breast cancers. One patient was diagnosed with breast cancer 2 years after a bilateral risk-reducing mastectomy. The most common breast cancer subtype was triple-negative breast cancer (73.68%). The patients could receive surgery, chemotherapy, endocrine therapy and radiotherapy. 18 patients had neoadjuvant chemotherapy, in 6 of these patients a complete pathological response (ypT0N0) was achieved.
Conclusions.Oncoplastic bilateral risk-reducing mastectomies are effective and safe procedures.
Streszczenie
Introduction.Breast cancer gene 1 and 2 (BRCA1/2) mutation carriers are at a higher risk of developing breast cancer. There are several established risk-reducing therapies. Our study aimed to characterize the BRCA1/2 mutation carriers, and to evaluate the implemented treatment methods.
Material and methods.A retrospective analysis of clinical records of 96 female patients hospitalized from October 2019 to December 2022 in the Breast Cancer Unit in Lodz, Poland.
Results.Out of 85 BRCA1 and 11 BRCA2 mutation carriers, 96.88% received nipple-sparing or skin-sparing, unilateral or bilateral risk-reducing mastectomies. Out of all the patients, 36 developed 38 breast cancers. One patient was diagnosed with breast cancer 2 years after a bilateral risk-reducing mastectomy. The most common breast cancer subtype was triple-negative breast cancer (73.68%). The patients could receive surgery, chemotherapy, endocrine therapy and radiotherapy. 18 patients had neoadjuvant chemotherapy, in 6 of these patients a complete pathological response (ypT0N0) was achieved.
Conclusions.Oncoplastic bilateral risk-reducing mastectomies are effective and safe procedures.
Słowa kluczowe
breast cancer gene 1/2; breast cancer; risk-reducing mastectomy; hereditary breast cancer; breast cancer unit
Informacje o artykuleTytuł
Retrospective analysis of the treatment of BRCA1 and BRCA2 mutation carriers – the experience of a single-center tertiary institution
Czasopismo
Biuletyn Polskiego Towarzystwa Onkologicznego Nowotwory
Numer
Typ artykułu
Praca badawcza (oryginalna)
Strony
325-330
Opublikowany online
2023-08-21
Wyświetlenia strony
70
Wyświetlenia/pobrania artykułu
162
Rekord bibliograficzny
Biuletyn Polskiego Towarzystwa Onkologicznego Nowotwory 2023;8(5):325-330.
Słowa kluczowe
breast cancer gene 1/2
breast cancer
risk-reducing mastectomy
hereditary breast cancer
breast cancer unit
Autorzy
Grzegorz J. Stępień
Thomas Wow
Agnieszka Kołacińska-Wow
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