Tom 8, Nr 2 (2023)
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Opublikowany online: 2023-02-23
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Neutrophil-to-lymphocyte ratio (NLR) as a prognostic factor in patients during palliative treatment of pancreatic ductal adeoncarcinoma with FOLFIRINOX regimen
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Biuletyn Polskiego Towarzystwa Onkologicznego Nowotwory 2023;8(2):83-86.
Streszczenie
Introduction.Difficulties in advanced pancreatic ductal adenocarcinoma (PDAC) treatment require a constant search for novel prognostic factors. The aim of this study is to determine the role of various morphological parameters in predicting the prognosis of advanced PDAC during systemic therapy with a FOLFIRINOX regimen.
Material and methods.The data of 52 patients, treated with FOLFIRINOX chemotherapy due to metastatic PDAC were analyzed retrospectively in this study.
Results.The median time of overall survival (OS) in the group of patients with neutrophil-to-lymphocyte ratio (NLR) ≥3 was 5.8 months, compared to 14.5 months in patients with NLR < 3. Median progression-free survival (PFS) in patients with NLR ≥ 3 was 4.1 months, compared to 8.5 months in patients with NLR < 3. There were no statistically significant differences among patients concerning the lymphocyte-to-monocyte ratio (LMR) and platelets-to-lymphocyte ratio (PLR).
Conclusions.Higher NLR is a negative prognostic factor in metastatic PDAC.
Słowa kluczowe: pancreatic ductal carcinomachemotherapyoverall survivaltime to progressionneutrophil-to-lymphocyte ratiolymphocyte-to-monocyte ratioplatelets-to-lymphocyte ratio
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