dostęp otwarty
The impact of neck lymph node volumetric status on local control of the primary tumour (LTC) in radiotherapy for oral cavity and oropharyngeal cancer
Afiliacje- Dept. Radiotherapy, M. Sklodowska-Curie National Research Institute of Oncology, Gliwice Branch, Poland
- Div. Research Programmes, M. Sklodowska-Curie National Research Institute of Oncology, Gliwice Branch, Poland
dostęp otwarty
Streszczenie
The study analyses the impact of volumetric nodal involvement (total nodal volume – TNV) on local control of the primary tumour (LTC) in radiotherapy for oral cavity and oropharyngeal cancer. The results show a significant decrease of the LTC (within a constant GTV) by about 10–20%, when the TNV increases from 10 to 40 cm3. It suggests delivering an extra boost dose of 3–4 extra fractions of 2.0 Gy fractions to the primary tumour in the case of nodal involvement (initial total nodal volume).
Streszczenie
The study analyses the impact of volumetric nodal involvement (total nodal volume – TNV) on local control of the primary tumour (LTC) in radiotherapy for oral cavity and oropharyngeal cancer. The results show a significant decrease of the LTC (within a constant GTV) by about 10–20%, when the TNV increases from 10 to 40 cm3. It suggests delivering an extra boost dose of 3–4 extra fractions of 2.0 Gy fractions to the primary tumour in the case of nodal involvement (initial total nodal volume).
Słowa kluczowe
total nodal volume; local tumour control; extra boost dose
Informacje o artykuleTytuł
The impact of neck lymph node volumetric status on local control of the primary tumour (LTC) in radiotherapy for oral cavity and oropharyngeal cancer
Czasopismo
Biuletyn Polskiego Towarzystwa Onkologicznego Nowotwory
Numer
Typ artykułu
Praca badawcza (oryginalna)
Strony
94-98
Opublikowany online
2021-02-08
Wyświetlenia strony
221
Wyświetlenia/pobrania artykułu
123
Rekord bibliograficzny
Biuletyn Polskiego Towarzystwa Onkologicznego Nowotwory 2021;6(2):94-98.
Słowa kluczowe
total nodal volume
local tumour control
extra boost dose
Autorzy
Marcin Miszczyk
Bogusław Maciejewski
Magdalena Markowska
Referencje (16)- Brenner DJ. Dose, volume, and tumor-control predictions in radiotherapy. Int J Radiat Oncol Biol Phys. 1993; 26(1): 171–179.
- Peters LJ, Wendt CD. Tumor volume as a predictor of radiocurability--a drop in the bucket? Int J Radiat Oncol Biol Phys. 1990; 19(2): 497–498.
- Mukherji SK, Schmalfuss IM, Castelijns J, et al. Clinical applications of tumor volume measurements for predicting outcome in patients with squamous cell carcinoma of the upper aerodigestive tract. AJNR Am J Neuroradiol. 2004; 25(8): 1425–1432.
- Plataniotis GA, Theofanopoulou ME, Kalogera-Fountzila A, et al. Prognostic impact of tumor volumetry in patients with locally advanced head-and-neck carcinoma (non-nasopharyngeal) treated by radiotherapy alone or combined radiochemotherapy in a randomized trial. Int J Radiat Oncol Biol Phys. 2004; 59(4): 1018–1026.
- Studer G, Lütolf UM, El-Bassiouni M, et al. Volumetric staging (VS) is superior to TNM and AJCC staging in predicting outcome of head and neck cancer treated with IMRT. Acta Oncol. 2007; 46(3): 386–394.
- Been MJ, Watkins J, Manz RM, et al. Tumor volume as a prognostic factor in oropharyngeal squamous cell carcinoma treated with primary radiotherapy. Laryngoscope. 2008; 118(8): 1377–1382.
- Knegjens JL, Hauptmann M, Pameijer FA, et al. Tumor volume as prognostic factor in chemoradiation for advanced head and neck cancer. Head Neck. 2011; 33(3): 375–382.
- Studer G, Rordorf T, Glanzmann C. Impact of tumor volume and systemic therapy on outcome in patients undergoing IMRT for large volume head neck cancer. Radiat Oncol. 2011; 6: 120.
- Fowler JF. Practical Time-Dose evaluation, or how to stop working and learn to love Linear Quadratics. In: Lewitt S, Purdy J, Perez C, Poortmans p. ed. Technical Basis of radiation therapy. Practical clinical applications. Heidelberg Springer, Berlin 2012: 3–31.
- Mc Br, Withers HR. Biological basis of radiation therapy. In: Perez and Brady’s Principle and Practice of Radiation Oncology, 5th ed. Lippincott, Williams and Williams, Philadelphia 208: 78–108.
- Maciejewski B, Withers HR, Taylor JM, et al. Dose fractionation and regeneration in radiotherapy for cancer of the oral cavity and oropharynx: tumor dose-response and repopulation. Int J Radiat Oncol Biol Phys. 1989; 16(3): 831–843.
- Harwood AR, Beale FA, Cummings BJ, et al. Supraglottic laryngeal carcinoma: an analysis of dose-time-volume factors in 410 patients. Int J Radiat Oncol Biol Phys. 1983; 9(3): 311–319.
- Van de, Ostoya F. van der Schueren E. The different clinical presentation, behavior and prognostic of carcinomas originating in the epilarynx and the lower supraglottis. Radiother Oncol. 1983; 1: 117–131.
- Wall TJ, Peters LJ, Brown BW, et al. Relationship between lymph nodal status and primary tumor control probability in tumors of the supraglottic larynx. Int J Radiat Oncol Biol Phys. 1985; 11(11): 1895–1902.
- Peters LJ, Withers HR, Thames HD, et al. Tumor radioresistance in clinical radiotherapy. Int J Radiat Oncol Biol Phys. 1982; 8(1): 101–108.
- Holm LE. Cellular DNA amounts of squamous cell carcinomas of the head and neck region in relation to prognosis. Laryngoscope. 1982; 92(9 Pt 1): 1064–1069.
