Wound healing in older oncologic patients
Streszczenie
The wound itself, along with lymphatic oedema, nausea and vomiting, fatigue and psychological stress, is listed as one of the five factors most negatively influencing cancer patients. Current oncologic treatment strategies are based on multimodal protocols including surgery, radiation and chemotherapeutic regimens. Thus, in oncology we can have a patient with a surgical wound, a wound that is a complication from radio- or chemotherapy, or a wound due to cancer progression. With increasing age, skin functions deteriorate due to the quantitative and qualitative changes of skin cells. Despite this, it seems that wound healing in healthy older patients is only delayed, but not completely defective. This effect is clinically apparent by the age of 60 and becomes significant at the age of 70. In turn, scar maturation improves in comparison with young individuals. However, the skin alone is more susceptible to injury in older patients. As older patients are qualified for complex oncologic treatment more and more often, wound healing in older cancer patients has become a matter of critical importance.
Słowa kluczowe: older oncologic patientselderlywound healing
Referencje
- Hurria A, Gupta S, Zauderer M, et al. Developing a cancer-specific geriatric assessment: a feasibility study. Cancer. 2005; 104(9): 1998–2005.
- Sen CK, Gordillo GM, Roy S, et al. Human skin wounds: a major and snowballing threat to public health and the economy. Wound Repair Regen. 2009; 17(6): 763–771.
- Margolis D. The Incidence and Prevalence of Pressure Ulcers among Elderly Patients in General Medical Practice. Ann Epidemiol. 2002; 12(5): 321–325.
- MedMarket Diligence, LLC; Report #S190 and Report #S249 (Worldwide Wound Management, Forecast to 2024: Established and Emerging Products, Technologies and Markets in the Americas, Europe, Asia/Pacific and Rest of World. December 2015 Report #S251).
- Lindsay E, Renyi R, Wilkie P, et al. Patient-centred care: a call to action for wound management. J Wound Care. 2017; 26(11): 662–677.
- Hawthorn M. Caring for a patient with a fungating malignant lesion in a hospice setting: reflecting on practice. Int J Palliat Nurs. 2010; 16(2): 70–2, 74, 76.
- Shaw TJ, Martin P. Wound repair at a glance. J Cell Sci. 2009; 122(Pt 18): 3209–3213.
- Cañedo-Dorantes L, Cañedo-Ayala M. Skin Acute Wound Healing: A Comprehensive Review. Int J Inflam. 2019; 2019: 3706315.
- Wicke C, Bachinger A, Coerper S, et al. Aging influences wound healing in patients with chronic lower extremity wounds treated in a specialized Wound Care Center. Wound Repair Regen. 2009; 17(1): 25–33.
- Stojadinovic O, Minkiewicz J, Sawaya A, et al. Deep tissue injury in development of pressure ulcers: a decrease of inflammasome activation and changes in human skin morphology in response to aging and mechanical load. PLoS One. 2013; 8(8): e69223.
- Hardman MJ, Ashcroft GS. Estrogen, not intrinsic aging, is the major regulator of delayed human wound healing in the elderly. Genome Biol. 2008; 9(5): R80.
- Gosain A, DiPietro LA. Aging and wound healing. World J Surg. 2004; 28(3): 321–326.
- Wicke C, Bachinger A, Coerper S, et al. Aging influences wound healing in patients with chronic lower extremity wounds treated in a specialized Wound Care Center. Wound Repair Regen. 2009; 17(1): 25–33.
- DiPietro LA. Wound healing: the role of the macrophage and other immune cells. Shock. 1995; 4(4): 233–240.
- Ashcroft G, Mills S, Ashworth J. Ageing and wound healing. Biogerontology. 2002; 3(6): 337–345.
- Roberts SB, Rosenberg I. Nutrition and aging: changes in the regulation of energy metabolism with aging. Physiol Rev. 2006; 86(2): 651–667.
- Sgonc R, Gruber J. Age-Related Aspects of Cutaneous Wound Healing: A Mini-Review. Regenerative and Technological Section / Mini-Review. Gerontology. 2013; 59: 159–164.
- Guo S, Dipietro LA. Factors affecting wound healing. J Dent Res. 2010; 89(3): 219–229.
- Schäfer M, Werner S. Cancer as an overhealing wound: an old hypothesis revisited. Nat Rev Mol Cell Biol. 2008; 9(8): 628–638.
