dostęp otwarty
A review of combined treatment strategies for HPV(+), p16(+) oropharyngeal cancer – is de-escalated radiotherapy a convincing and promising paradigm?
Afiliacje- Div. Research Programmes
- Radiotherapy and Chemotherapy Ward I, M. Skłodowska-Curie National Research Institute of Oncology, Branch Gliwice
dostęp otwarty
Streszczenie
Biological and clinical interest on HPV-associated oropharyngeal cancer (OPC) is rapidly increasing. The genetic and biological characteristics of HPV and p16 expression are presented. The significantly better prognosis (overall survival, locoregional control) of HPV p16(+) OPC patients has been well documented. The leading studies and clinical trials in this field are selected and discussed in details. There is a convincing suggestion that some, low-risk HPV(+) OPC patients might be overtreated. Different approaches with varying degrees of radiotherapy dose de-intensification are critically reviewed and the current de-escalated treatment paradigms are presented and discussed.
Streszczenie
Biological and clinical interest on HPV-associated oropharyngeal cancer (OPC) is rapidly increasing. The genetic and biological characteristics of HPV and p16 expression are presented. The significantly better prognosis (overall survival, locoregional control) of HPV p16(+) OPC patients has been well documented. The leading studies and clinical trials in this field are selected and discussed in details. There is a convincing suggestion that some, low-risk HPV(+) OPC patients might be overtreated. Different approaches with varying degrees of radiotherapy dose de-intensification are critically reviewed and the current de-escalated treatment paradigms are presented and discussed.
Słowa kluczowe
HPV-associated OPC; treatment outcome; de-escalated therapy paradigms
Informacje o artykuleTytuł
A review of combined treatment strategies for HPV(+), p16(+) oropharyngeal cancer – is de-escalated radiotherapy a convincing and promising paradigm?
Czasopismo
Biuletyn Polskiego Towarzystwa Onkologicznego Nowotwory
Numer
Typ artykułu
Artykuł przeglądowy
Strony
327-334
Opublikowany online
2020-12-03
Wyświetlenia strony
374
Wyświetlenia/pobrania artykułu
115
Rekord bibliograficzny
Biuletyn Polskiego Towarzystwa Onkologicznego Nowotwory 2020;5(6):327-334.
Słowa kluczowe
HPV-associated OPC
treatment outcome
de-escalated therapy paradigms
Autorzy
Bogusław Maciejewski
Krzysztof Składowski
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