dostęp otwarty
Gut microbiota and neoplastic diseases of the gastrointestinal tract
, 1, 2
Afiliacje- Maria Sklodowska-Curie National Research Institute of Oncology, Gliwice Branch
- Medical Specialist Centre in Gliwice
dostęp otwarty
Streszczenie
The term “microbiome” is used to describe the substantial number and diverse spectrum of microorganisms that inhabit the body. It plays an essential role in health conditions and diseases. Recent years have brought a further intensification of experimental studies on the impact of the microbiome on the human body, particularly with the aim of identifying and clarifying this impact. Many studies indicate that diet, lifestyle and drugs can affect the composition of the intestinal microflora, which, in turn, can modulate the development and progression of gastrointestinal tract tumors. It is suspected that the gut microbiome plays a significant role in the formation of gastrointestinal tumors. On the other hand, the role of the intestinal microflora in inhibiting the processes of oncogenesis suggests that this mechanism may be used to prevent and treat gastrointestinal cancer. Using probiotics to modify the microbiome may be beneficial in cancer therapy and may be used as a supportive treatment for classic cancer therapies such as chemotherapy, radiotherapy and surgical treatment. Intestinal microbiome analysis can be potentially used to develop non-invasive diagnostic tests. These tests could be useful as new protective markers for colorectal cancer, or as prognostic markers and predictive markers of response to treatment, especially immunotherapy.
Streszczenie
The term “microbiome” is used to describe the substantial number and diverse spectrum of microorganisms that inhabit the body. It plays an essential role in health conditions and diseases. Recent years have brought a further intensification of experimental studies on the impact of the microbiome on the human body, particularly with the aim of identifying and clarifying this impact. Many studies indicate that diet, lifestyle and drugs can affect the composition of the intestinal microflora, which, in turn, can modulate the development and progression of gastrointestinal tract tumors. It is suspected that the gut microbiome plays a significant role in the formation of gastrointestinal tumors. On the other hand, the role of the intestinal microflora in inhibiting the processes of oncogenesis suggests that this mechanism may be used to prevent and treat gastrointestinal cancer. Using probiotics to modify the microbiome may be beneficial in cancer therapy and may be used as a supportive treatment for classic cancer therapies such as chemotherapy, radiotherapy and surgical treatment. Intestinal microbiome analysis can be potentially used to develop non-invasive diagnostic tests. These tests could be useful as new protective markers for colorectal cancer, or as prognostic markers and predictive markers of response to treatment, especially immunotherapy.
Słowa kluczowe
microbiome; gastrointestinal cancer; probiotics
Pliki uzupełniające/dodatkowe (1)
Informacje o artykuleTytuł
Gut microbiota and neoplastic diseases of the gastrointestinal tract
Czasopismo
Biuletyn Polskiego Towarzystwa Onkologicznego Nowotwory
Numer
Strony
200-202
Opublikowany online
2020-07-28
Wyświetlenia strony
251
Wyświetlenia/pobrania artykułu
106
Rekord bibliograficzny
Biuletyn Polskiego Towarzystwa Onkologicznego Nowotwory 2020;5(4):200-202.
Słowa kluczowe
microbiome
gastrointestinal cancer
probiotics
Autorzy
Aleksandra Pilśniak
Urszula Dworzecka
Ewa Otto-Buczkowska
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