dostęp otwarty
Overall and GTV subvolumes tumour control probability (TCP) for head and neck cancer treated by 3D-IMRT with inhomogeneous dose distribution
Afiliacje- Department RT Planning, M. Skłodowska-Curie National Research Institute of Oncology, Gliwice Branch
- Department Radiotherapy, M. Skłodowska-Curie National Research Institute of Oncology, Gliwice Branch
- Klinik und Poliklinik für Strahlentherapie der Technischen Universität München, Germany
- Faculty of Health Sciences, Department of Public Health Medical University, Wroclaw
- Division Research Programmes, M. Skłodowska-Curie National Research Institute of Oncology, Gliwice Branch
dostęp otwarty
Streszczenie
Introduction. In this study, an original model has been developed to estimate the real TCP that is a product of the TCPs calculated for GTV subvolumes of head and neck cancer based on 3D-IMRT dose planning.
Material and methods. Retrospective pilot group consist of 16 cases of oropharyngeal cancer in stage T1–2N0 previously treated with 3D-IMRT with at least 3-year follow-up. The total dose (TD) was 60–70 Gy in 2.0 Gy fractions delivered over 42–49 days. Within GTV two subvolumes were marked out: SVA with the planned 100% TD, and underdosed (90–95%) SVB. The TCP for both was calculated using the original formula developed by Withers and Maciejewski.
Results. During 3-year follow-up, 8 local recurrences (LR) occurred. In about 70% of SVB “dose cold spots” encompassed more than 50% GTV volume. This resulted in the TCPSVB decrease to 60%. Thus, the real overall TCP was much lower than a priori predicted, and in these cases local recurrences occurred.
Discussion.Both cold spot SVB volumes and their dose deficit strongly correlated with a high risk of LR.
Conclusions.In conclusion the magnitude of dose deficit and the size of cold subvolume within GTV have an independent negative impact on real TCP and demand dose re-planning.
Streszczenie
Introduction. In this study, an original model has been developed to estimate the real TCP that is a product of the TCPs calculated for GTV subvolumes of head and neck cancer based on 3D-IMRT dose planning.
Material and methods. Retrospective pilot group consist of 16 cases of oropharyngeal cancer in stage T1–2N0 previously treated with 3D-IMRT with at least 3-year follow-up. The total dose (TD) was 60–70 Gy in 2.0 Gy fractions delivered over 42–49 days. Within GTV two subvolumes were marked out: SVA with the planned 100% TD, and underdosed (90–95%) SVB. The TCP for both was calculated using the original formula developed by Withers and Maciejewski.
Results. During 3-year follow-up, 8 local recurrences (LR) occurred. In about 70% of SVB “dose cold spots” encompassed more than 50% GTV volume. This resulted in the TCPSVB decrease to 60%. Thus, the real overall TCP was much lower than a priori predicted, and in these cases local recurrences occurred.
Discussion.Both cold spot SVB volumes and their dose deficit strongly correlated with a high risk of LR.
Conclusions.In conclusion the magnitude of dose deficit and the size of cold subvolume within GTV have an independent negative impact on real TCP and demand dose re-planning.
Słowa kluczowe
3D-IMRT planning; cold spots within GTV; estimates of partial TCPs within GTV subvolumes
Informacje o artykuleTytuł
Overall and GTV subvolumes tumour control probability (TCP) for head and neck cancer treated by 3D-IMRT with inhomogeneous dose distribution
Czasopismo
Biuletyn Polskiego Towarzystwa Onkologicznego Nowotwory
Numer
Strony
176-183
Opublikowany online
2020-07-28
Wyświetlenia strony
225
Wyświetlenia/pobrania artykułu
120
Rekord bibliograficzny
Biuletyn Polskiego Towarzystwa Onkologicznego Nowotwory 2020;5(4):176-183.
Słowa kluczowe
3D-IMRT planning
cold spots within GTV
estimates of partial TCPs within GTV subvolumes
Autorzy
Leszek Hawrylewicz
Bogusław Maciejewski
Klaus Rudiger Trott
Andrzej Tukiendorf
Leszek Miszczyk
Magdalena Markowska
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