dostęp otwarty
Oncogeriatrics (part 5.). The role of comorbidities in older patients with cancer
Afiliacje- Department of General, Oncological and Geriatric Surgery, Jagiellonian University Medical College, Kraków
dostęp otwarty
Streszczenie
Comorbidity is defined as the presence of one or more additional conditions co-occurring with primary indices. Comorbidity is common in older cancer patients. Its prevalence, however, is difficult to determine and varies by cancer site. There is no single reason for which comorbidity and cancer coexist, but chronic diseases and cancer are both common in older age and share many risk factors.
There is no consensus on how should comorbidity be measured. Even though many comorbidity indices have been developed so far, no unified, widely used instrument exists.
Patients with comorbidities have worse outcomes compared to those with no such conditions. They may experience diagnostic and therapeutic delay and be disqualified from radical treatment more often. Moreover, they are more likely to suffer from treatment-related complications and have worse overall survival.
It seems important to assess the comorbidity status as a part of individualised oncologic treatment planning. However, as data regarding its significance are insufficient and in many cases conflicting, patients with comorbidity should not be routinely considered as not fit enough for a radical treatment. Therefore, to adequately address all of the concerns that have been raised, a broader participation of older, comorbid patients in clinical trials is needed.
Streszczenie
Comorbidity is defined as the presence of one or more additional conditions co-occurring with primary indices. Comorbidity is common in older cancer patients. Its prevalence, however, is difficult to determine and varies by cancer site. There is no single reason for which comorbidity and cancer coexist, but chronic diseases and cancer are both common in older age and share many risk factors.
There is no consensus on how should comorbidity be measured. Even though many comorbidity indices have been developed so far, no unified, widely used instrument exists.
Patients with comorbidities have worse outcomes compared to those with no such conditions. They may experience diagnostic and therapeutic delay and be disqualified from radical treatment more often. Moreover, they are more likely to suffer from treatment-related complications and have worse overall survival.
It seems important to assess the comorbidity status as a part of individualised oncologic treatment planning. However, as data regarding its significance are insufficient and in many cases conflicting, patients with comorbidity should not be routinely considered as not fit enough for a radical treatment. Therefore, to adequately address all of the concerns that have been raised, a broader participation of older, comorbid patients in clinical trials is needed.
Słowa kluczowe
older patient; comorbidity; multimorbidity; frailty
Informacje o artykuleTytuł
Oncogeriatrics (part 5.). The role of comorbidities in older patients with cancer
Czasopismo
Biuletyn Polskiego Towarzystwa Onkologicznego Nowotwory
Numer
Strony
71-76
Opublikowany online
2020-04-10
Wyświetlenia strony
240
Wyświetlenia/pobrania artykułu
126
Rekord bibliograficzny
Biuletyn Polskiego Towarzystwa Onkologicznego Nowotwory 2020;5(2):71-76.
Słowa kluczowe
older patient
comorbidity
multimorbidity
frailty
Autorzy
Urszula Skorus
Jakub Kenig
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