dostęp otwarty
Should perioperative chemotherapy in triple negative breast cancer routinely comprise platinum salts? A vote for no
- Department and Chair of Electroradiology, Chemotherapy Department, The Maria Skłodowska–Curie Greater Poland Cancer Centre, Poznan University of Medical Sciences, Poznan
dostęp otwarty
Streszczenie
Breast cancer is the most common female neoplasm in Poland and worldwide, its mortality rate ranking second only to lung cancer. There are several biological subtypes, differing, among other parameters, as to prognosis and perioperative treatment recommendations. Triple negative breast cancer is one of the worst prognoses and systemic preoperative treatment is recommended as early as of II TNM stage. Pathological complete response (pCR) may result in an improved prognosis. Most patients respond well to standard chemotherapy and there is no need to include platinum derivatives in perioperative therapies. One should remember that platinum salts use not only increases the percentage of pCRs, but also results in an increased therapeutic toxicity; it does not, however, have an impact on disease free survival (DFS) an overall survival (OS).
Streszczenie
Breast cancer is the most common female neoplasm in Poland and worldwide, its mortality rate ranking second only to lung cancer. There are several biological subtypes, differing, among other parameters, as to prognosis and perioperative treatment recommendations. Triple negative breast cancer is one of the worst prognoses and systemic preoperative treatment is recommended as early as of II TNM stage. Pathological complete response (pCR) may result in an improved prognosis. Most patients respond well to standard chemotherapy and there is no need to include platinum derivatives in perioperative therapies. One should remember that platinum salts use not only increases the percentage of pCRs, but also results in an increased therapeutic toxicity; it does not, however, have an impact on disease free survival (DFS) an overall survival (OS).
Słowa kluczowe
breast cancer; triple negative breast cancer; perioperative therapy; platinum salts
Tytuł
Should perioperative chemotherapy in triple negative breast cancer routinely comprise platinum salts? A vote for no
Czasopismo
Biuletyn Polskiego Towarzystwa Onkologicznego Nowotwory
Numer
Strony
235-236
Opublikowany online
2020-01-09
Wyświetlenia strony
193
Wyświetlenia/pobrania artykułu
97
Rekord bibliograficzny
Biuletyn Polskiego Towarzystwa Onkologicznego Nowotwory 2019;4(5-6):235-236.
Słowa kluczowe
breast cancer
triple negative breast cancer
perioperative therapy
platinum salts
Autorzy
Joanna Kufel-Grabowska