dostęp otwarty
HE4 – not only an ovarian cancer biomarker – a brief review
Afiliacje- Students’ Scientific Organization of Cancer Cell Biology, Department of Cancer Prevention, Medical University of Warsaw
- Department of Cancer Prevention, Medical University of Warsaw
dostęp otwarty
Streszczenie
Human epididymis protein 4 (HE4) was firstly identified in epididymal epithelial cells and described as a protease inhibitor playing a role in spermatogenesis. Regarding numerous studies proving its diverse potential as a prognostic and predictive factor in ovarian cancer, it was incorporated into ROMA algorithm. Nevertheless, recent studies have shown that serum level of HE4 is not exclusive to ovarian cancer. As a result, doctors using ROMA algorithm for stratifying patients with ovarian cancer must be aware of other conditions that may affect serum level of HE4. This review comprises different conditions connected with high level of HE4 that might impact ovarian cancer diagnosing process. Moreover, discovering increased HE4 level in various conditions should open discussion about its applicability in diseases other than ovarian cancer.
Streszczenie
Human epididymis protein 4 (HE4) was firstly identified in epididymal epithelial cells and described as a protease inhibitor playing a role in spermatogenesis. Regarding numerous studies proving its diverse potential as a prognostic and predictive factor in ovarian cancer, it was incorporated into ROMA algorithm. Nevertheless, recent studies have shown that serum level of HE4 is not exclusive to ovarian cancer. As a result, doctors using ROMA algorithm for stratifying patients with ovarian cancer must be aware of other conditions that may affect serum level of HE4. This review comprises different conditions connected with high level of HE4 that might impact ovarian cancer diagnosing process. Moreover, discovering increased HE4 level in various conditions should open discussion about its applicability in diseases other than ovarian cancer.
Słowa kluczowe
human epididymis protein 4; ovarian cancer; ROMA algorithm; biomarkers
Informacje o artykuleTytuł
HE4 – not only an ovarian cancer biomarker – a brief review
Czasopismo
Biuletyn Polskiego Towarzystwa Onkologicznego Nowotwory
Numer
Strony
177-180
Opublikowany online
2019-10-17
Wyświetlenia strony
386
Wyświetlenia/pobrania artykułu
180
Rekord bibliograficzny
Biuletyn Polskiego Towarzystwa Onkologicznego Nowotwory 2019;4(3-4):177-180.
Słowa kluczowe
human epididymis protein 4
ovarian cancer
ROMA algorithm
biomarkers
Autorzy
Marta Maksimiuk
Michał P. Budzik
Andrzej Deptała
Anna M. Badowska-Kozakiewicz
