dostęp otwarty
Three secondary malignant neoplasms in a childhood cancer survivor positive for nibrin gene mutation – a case report and literature review
dostęp otwarty
Streszczenie
Childhood cancer survivors often develop subsequent neoplasms secondary to radio- (RT) or chemotherapy (CHT). Risk factors for the secondary tumors are the female gender, older age at diagnosis, Hodgkin’s lymphoma treatment and the use of RT. The cumulative incidence of the second malignant neoplasm, excluding non-melanoma skin cancer, 30 years after the childhood cancer diagnosis is around 8% [1]. We present the case of a patient who developed three independent malignancies following radical treatment of nephroblastoma (Wilms’ tumor; WT) in childhood, found at the age of 53 to be a carrier of the 657_661delACAAA (p. Lys219fs) mutation in the 6/16 exon of the nibrin coding gene (NBN).
Streszczenie
Childhood cancer survivors often develop subsequent neoplasms secondary to radio- (RT) or chemotherapy (CHT). Risk factors for the secondary tumors are the female gender, older age at diagnosis, Hodgkin’s lymphoma treatment and the use of RT. The cumulative incidence of the second malignant neoplasm, excluding non-melanoma skin cancer, 30 years after the childhood cancer diagnosis is around 8% [1]. We present the case of a patient who developed three independent malignancies following radical treatment of nephroblastoma (Wilms’ tumor; WT) in childhood, found at the age of 53 to be a carrier of the 657_661delACAAA (p. Lys219fs) mutation in the 6/16 exon of the nibrin coding gene (NBN).
Słowa kluczowe
leiomyosarcoma, secondary neoplasms, radiotherapy, nibrin
Tytuł
Three secondary malignant neoplasms in a childhood cancer survivor positive for nibrin gene mutation – a case report and literature review
Czasopismo
Biuletyn Polskiego Towarzystwa Onkologicznego Nowotwory
Numer
Strony
79-80
Opublikowany online
2019-08-09
Wyświetlenia strony
231
Wyświetlenia/pobrania artykułu
287
Rekord bibliograficzny
Biuletyn Polskiego Towarzystwa Onkologicznego Nowotwory 2019;4(2):79-80.
Słowa kluczowe
leiomyosarcoma
secondary neoplasms
radiotherapy
nibrin
Autorzy
Anna Romanowska
Joanna Gajda
Jacek Jassem
Rafał Pęksa
Renata Zaucha