dostęp otwarty
SOX10 as an immunohistochemical marker in cancer diagnostics
dostęp otwarty
Streszczenie
SOX10 is a transcription factor that plays an important role in the formation, specification and differentiation of neural crest cells. Recent studies indicate that this protein is expressed in tumors of the nervous system, salivary glands, breast, soft tissues and melanoma cells. Due to its higher sensitivity and specificity in comparison to other available markers, SOX10 protein is mainly used in the diagnosis of malignant peripheral nerve sheet tumor and primary and metastatic melanoma including desmoplastic type. SOX10 has a more readable immunohistochemical staining, which also facilitates histopathological interpretation. Several monoclonal and polyclonal antibodies for diagnostics are currently available. Unification of anti-SOX10 antibodies to increase specificity, eliminate variability and strength of immunohistochemical reactions will support its diagnostic usefulness.
Streszczenie
SOX10 is a transcription factor that plays an important role in the formation, specification and differentiation of neural crest cells. Recent studies indicate that this protein is expressed in tumors of the nervous system, salivary glands, breast, soft tissues and melanoma cells. Due to its higher sensitivity and specificity in comparison to other available markers, SOX10 protein is mainly used in the diagnosis of malignant peripheral nerve sheet tumor and primary and metastatic melanoma including desmoplastic type. SOX10 has a more readable immunohistochemical staining, which also facilitates histopathological interpretation. Several monoclonal and polyclonal antibodies for diagnostics are currently available. Unification of anti-SOX10 antibodies to increase specificity, eliminate variability and strength of immunohistochemical reactions will support its diagnostic usefulness.
Słowa kluczowe
SOX10 protein, immunohistochemistry, melanocytic marker, malignant peripheral nerve sheath tumor, anti-SOX10 antibodies
Informacje o artykuleTytuł
SOX10 as an immunohistochemical marker in cancer diagnostics
Czasopismo
Biuletyn Polskiego Towarzystwa Onkologicznego Nowotwory
Numer
Strony
72-78
Opublikowany online
2019-08-09
Wyświetlenia strony
1756
Wyświetlenia/pobrania artykułu
606
Rekord bibliograficzny
Biuletyn Polskiego Towarzystwa Onkologicznego Nowotwory 2019;4(2):72-78.
Słowa kluczowe
SOX10 protein
immunohistochemistry
melanocytic marker
malignant peripheral nerve sheath tumor
anti-SOX10 antibodies
Autorzy
Beata Pytlak
Monika Prochorec-Sobieszek
Anna Szumera-Ciećkiewicz
