dostęp otwarty
Bone marrow sparing RT in era of immunotherapy
dostęp otwarty
Streszczenie
Recent advances in the field of immunotherapy have changed the perception of cancer treatment to complex model with host immunity in the spotlight. Potential synergy of immunotherapy drugs [aiming cytotoxic T cell antigen 4 (CTLA-4) or programmed cell death-1/ligand (PD-1/PD-L1)] and radiotherapy (RT) have established basis for ongoing clinical trials testing combined treatment. It was shown that complete blood cell counts (CBC) parameters may correlate with cancer survival, toxicity and outcomes of treatment. Therefore, reduction of hematologic toxicity of cancer treatment may gain in significance. Modern dose delivery techniques compromise dose reduction in critical organs (like bone marrow — BM) with adequate irradiation of target volumes. In addition, usage of modern imaging like positron emission tomography (PET), magnetic resonance imaging (MRI) allows to divide the volume of BM to active and inactive one.
In this review, we discuss the synergy of RT and immunity and techniques of Bone Marrow Sparing RT (BMS-RT).
Streszczenie
Recent advances in the field of immunotherapy have changed the perception of cancer treatment to complex model with host immunity in the spotlight. Potential synergy of immunotherapy drugs [aiming cytotoxic T cell antigen 4 (CTLA-4) or programmed cell death-1/ligand (PD-1/PD-L1)] and radiotherapy (RT) have established basis for ongoing clinical trials testing combined treatment. It was shown that complete blood cell counts (CBC) parameters may correlate with cancer survival, toxicity and outcomes of treatment. Therefore, reduction of hematologic toxicity of cancer treatment may gain in significance. Modern dose delivery techniques compromise dose reduction in critical organs (like bone marrow — BM) with adequate irradiation of target volumes. In addition, usage of modern imaging like positron emission tomography (PET), magnetic resonance imaging (MRI) allows to divide the volume of BM to active and inactive one.
In this review, we discuss the synergy of RT and immunity and techniques of Bone Marrow Sparing RT (BMS-RT).
Słowa kluczowe
radiotherapy, intensity-modulated radiotherapy, bone marrow, red bone marrow, yellow bone marrow, immunotherapy, lymphopenia, neutropenia, thrombocytopenia, anaemia
Informacje o artykuleTytuł
Bone marrow sparing RT in era of immunotherapy
Czasopismo
Biuletyn Polskiego Towarzystwa Onkologicznego Nowotwory
Numer
Strony
389-395
Opublikowany online
2018-03-02
Wyświetlenia strony
599
Wyświetlenia/pobrania artykułu
513
Rekord bibliograficzny
Biuletyn Polskiego Towarzystwa Onkologicznego Nowotwory 2017;2(5):389-395.
Słowa kluczowe
radiotherapy
intensity-modulated radiotherapy
bone marrow
red bone marrow
yellow bone marrow
immunotherapy
lymphopenia
neutropenia
thrombocytopenia
anaemia
Autorzy
Łukasz Kuncman
Malwina Pietrzykowska-Kuncman
Justyna Danielska
Jolanta Łuniewska-Bury
Jacek Fijuth
