dostęp otwarty
Merkel cell carcinoma: literature review
- Basildon University Hospital, Wielka Brytania
dostęp otwarty
Streszczenie
Merkel cell carcinoma (MCC) was given a such name after the German histopathologist Friedrich Merkel, who first in 1875, described the Merkel cells, as small round or oval basophilic cells located at the end of nerve axons and within the basal layer of the epidermis. The current agreement about the function of Merkel cells they are associated with the nerve terminals acting as mechanoreceptors. MCC is a clinically aggressive uncommon, cutaneous neuroendocrine neoplastic tumour with a high mortality rate. Clinically may be presented as a painless, rapidly growing, dome-shaped red or purplish nodule. Usually in a sun-exposed area of the head and neck or upper limbs. Tremendous effort has been done in the last few years for a better understanding of the pathogenesis behind the MCC and the discovery of the Merkel cell polyomavirus suggests another clue to its pathogenesis. The expression of both epithelial and neuroendocrine immunohistochemical markers in the malignant cells, gives the tumour a unique feature that helps differentiate this neoplasm from other entities.
Streszczenie
Merkel cell carcinoma (MCC) was given a such name after the German histopathologist Friedrich Merkel, who first in 1875, described the Merkel cells, as small round or oval basophilic cells located at the end of nerve axons and within the basal layer of the epidermis. The current agreement about the function of Merkel cells they are associated with the nerve terminals acting as mechanoreceptors. MCC is a clinically aggressive uncommon, cutaneous neuroendocrine neoplastic tumour with a high mortality rate. Clinically may be presented as a painless, rapidly growing, dome-shaped red or purplish nodule. Usually in a sun-exposed area of the head and neck or upper limbs. Tremendous effort has been done in the last few years for a better understanding of the pathogenesis behind the MCC and the discovery of the Merkel cell polyomavirus suggests another clue to its pathogenesis. The expression of both epithelial and neuroendocrine immunohistochemical markers in the malignant cells, gives the tumour a unique feature that helps differentiate this neoplasm from other entities.
Słowa kluczowe
Merkel cell carcinoma, trabecular carcinoma, Toker tumour, polyomavirus
Tytuł
Merkel cell carcinoma: literature review
Czasopismo
Biuletyn Polskiego Towarzystwa Onkologicznego Nowotwory
Numer
Strony
160-164
Opublikowany online
2017-10-17
Wyświetlenia strony
326
Wyświetlenia/pobrania artykułu
454
Rekord bibliograficzny
Biuletyn Polskiego Towarzystwa Onkologicznego Nowotwory 2017;2(2):160-164.
Słowa kluczowe
Merkel cell carcinoma
trabecular carcinoma
Toker tumour
polyomavirus
Autorzy
Abdalla Saad Abdalla Al‐Zawi
Andrew Prodromou
Wayne Chicken
Turhan Comez
Ekin Deniz