Tom 9, Nr 5 (2024)
Artykuł przeglądowy
Opublikowany online: 2024-11-15
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The impact of cell phone use on the formation of brain tumors
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Biuletyn Polskiego Towarzystwa Onkologicznego Nowotwory 2024;9(5):349-356.
Streszczenie
Cell phone use is increasing and now includes nearly 6.9 billion subscribers. A common concern is the effect of long-lasting phone calls on the formation of brain tumors, due to the proximity of this region. The aim of the following review was to verify this association along with a potential molecular background. The results of epidemiological studies are inconclusive. Most of them do not indicate a significantly increased risk of central nervous system cancers in phone users. However, some indicate that there is an increased risk of gliomas and a worse prognosis for patients with long-term phone use (in terms of cumulative hours and number of calls). Experimental studies show that radiation emitted by phones is able to induce changes in cell biology by generating oxidative stress, causing DNA damage and affecting gene expression. Therefore, further observation of the population and evaluation of the results of ongoing studies is needed to accurately assess this risk.
Słowa kluczowe: brain tumorscell phonescarcinogenesispublic health
Referencje
- Miller KD, Ostrom QT, Kruchko C, et al. Brain and other central nervous system tumor statistics, 2021. CA Cancer J Clin. 2021; 71(5): 381–406.
- Lubińska-Żądło B, Pych A, Kowalczyk B, et al. The quality of life of patients with head neoplasms and incidence of depression treated with radiotherapy. A preliminary research report. Nowotwory. Journal of Oncology. 2021; 71(4): 212–219.
- Ostrom QT, Francis SS, Barnholtz-Sloan JS. Epidemiology of Brain and Other CNS Tumors. Curr Neurol Neurosci Rep. 2021; 21(12): 68.
- Miranda-Filho A, Piñeros M, Soerjomataram I, et al. Cancers of the brain and CNS: global patterns and trends in incidence. Neuro Oncol. 2017; 19(2): 270–280.
- Rugała Z. Long-term survival of a patient suffering from glioblastoma multiforme of the brain as well as kidney cancer diagnosed and treated simultaneously. Nowotwory. Journal of Oncology. 2018; 68(5): 268–272.
- Janus-Szymańska G, Waszczuk Ł, Jacków-Nowicka J. Znaczenie badań genetycznych i radiologicznych w diagnostyce i doborze terapii glejaków mózgu u dorosłych. Nowotwory. Journal of Oncology. 2021; 71(5): 328–334.
- Georgakis MK, Kalogirou EI, Liaskas A, et al. NARECHEM-BT Working Group. Anthropometrics at birth and risk of a primary central nervous system tumour: A systematic review and meta-analysis. Eur J Cancer. 2017; 75: 117–131.
- Amirian ES, Zhou R, Wrensch MR, et al. Approaching a Scientific Consensus on the Association between Allergies and Glioma Risk: A Report from the Glioma International Case-Control Study. Cancer Epidemiol Biomarkers Prev. 2016; 25(2): 282–290.
- Baan R, Grosse Y, Lauby-Secretan B, et al. WHO International Agency for Research on Cancer Monograph Working Group. Carcinogenicity of radiofrequency electromagnetic fields. Lancet Oncol. 2011; 12(7): 624–626; Erratum in: Lancet Oncol. 2015; 16(8): e379.
- Cellphone Radio Frequency Radiation Studies. National Toxicology Program. 2024. https://www.niehs.nih.gov/sites/default/files/NTP_cell_phone_factsheet_jan_2024_508.pdf (15.03.2024).
- Electromagnetic fields and public health: mobile phones. World Health Organisation. 2014. https://www.who.int/news-room/fact-sheets/detail/electromagnetic-fields-and-public-health-mobile-phones (15.03.2024).
- Cell Phones and Cancer Risk. National Cancer Institute. 2022. https://www.cancer.gov/about-cancer/causes-prevention/risk/radiation/cell-phones-fact-sheet#why-has-there-been-concern-that-cell-phones-may-cause-cancer (15.03.2024).
- Maciejewski B. Tumor and normal tissue radiation side effects. Nowotwory. Journal of Oncology. 2022; 72(4): 242–246.
- Smith-Roe SL, Wyde ME, Stout MD, et al. Evaluation of the genotoxicity of cell phone radiofrequency radiation in male and female rats and mice following subchronic exposure. Environ Mol Mutagen. 2020; 61(2): 276–290.
- Ruediger HW. Genotoxic effects of radiofrequency electromagnetic fields. Pathophysiology. 2009; 16(2-3): 89–102.
- Yakymenko I, Tsybulin O, Sidorik E, et al. Oxidative mechanisms of biological activity of low-intensity radiofrequency radiation. Electromagn Biol Med. 2016; 35(2): 186–202.
- Campisi A, Gulino M, Acquaviva R, et al. Reactive oxygen species levels and DNA fragmentation on astrocytes in primary culture after acute exposure to low intensity microwave electromagnetic field. Neurosci Lett. 2010; 473(1): 52–55.
- Panagopoulos DJ, Panagopoulos DJ. Chromosome damage in human cells induced by UMTS mobile telephony radiation. Gen Physiol Biophys. 2019; 38(5): 445–454.
- Singh KV, Prakash C, Nirala JP, et al. Acute radiofrequency electromagnetic radiation exposure impairs neurogenesis and causes neuronal DNA damage in the young rat brain. Neurotoxicology. 2023; 94: 46–58.
- Gherardini L, Ciuti G, Tognarelli S, et al. Searching for the perfect wave: the effect of radiofrequency electromagnetic fields on cells. Int J Mol Sci. 2014; 15(4): 5366–5387.
- Liu L, Huang B, Lu Y, et al. Interactions between electromagnetic radiation and biological systems. iScience. 2024; 27(3): 109201.
- Gupta SK, Mesharam MK, Krishnamurthy S. Electromagnetic radiation 2450 MHz exposure causes cognition deficit with mitochondrial dysfunction and activation of intrinsic pathway of apoptosis in rats. J Biosci. 2018; 43(2): 263–276.
- Zhao TY, Zou SP, Knapp PE. Exposure to cell phone radiation up-regulates apoptosis genes in primary cultures of neurons and astrocytes. Neurosci Lett. 2007; 412(1): 34–38.
- Durdik M, Kosik P, Markova E, et al. Microwaves from mobile phone induce reactive oxygen species but not DNA damage, preleukemic fusion genes and apoptosis in hematopoietic stem/progenitor cells. Sci Rep. 2019; 9(1): 16182.
- Hou Q, Wang M, Wu S, et al. Oxidative changes and apoptosis induced by 1800-MHz electromagnetic radiation in NIH/3T3 cells. Electromagn Biol Med. 2015; 34(1): 85–92.
- Shahabi S, Hassanzadeh Taji I, Hoseinnezhaddarzi M, et al. Exposure to cell phone radiofrequency changes corticotrophin hormone levels and histology of the brain and adrenal glands in male Wistar rat. Iran J Basic Med Sci. 2018; 21(12): 1269–1274.
- Falcioni L, Bua L, Tibaldi E, et al. Report of final results regarding brain and heart tumors in Sprague-Dawley rats exposed from prenatal life until natural death to mobile phone radiofrequency field representative of a 1.8 GHz GSM base station environmental emission. Environ Res. 2018; 165: 496–503.
- Al-Serori H, Ferk F, Kundi M, et al. Mobile phone specific electromagnetic fields induce transient DNA damage and nucleotide excision repair in serum-deprived human glioblastoma cells. PLoS One. 2018; 13(4): e0193677.
- Liu Yx, Li Gq, Fu Xp, et al. Exposure to 3G mobile phone signals does not affect the biological features of brain tumor cells. BMC Public Health. 2015; 15: 764.
- Ouadah NS, Lecomte A, Robidel F, et al. Possible effects of radiofrequency electromagnetic fields on in vivo C6 brain tumors in Wistar rats. J Neurooncol. 2018; 140(3): 539–546.
- Karipidis K, Mate R, Urban D, et al. 5G mobile networks and health-a state-of-the-science review of the research into low-level RF fields above 6 GHz. J Expo Sci Environ Epidemiol. 2021; 31(4): 585–605.
- Russell CL. 5 G wireless telecommunications expansion: Public health and environmental implications. Environ Res. 2018; 165: 484–495.
- Morgan LL, Miller AB, Sasco A, et al. Mobile phone radiation causes brain tumors and should be classified as a probable human carcinogen (2A) (review). Int J Oncol. 2015; 46(5): 1865–1871.
- Moon J, Moon J, Moon J. The relationship between radiofrequency-electromagnetic radiation from cell phones and brain tumor: The brain tumor incidence trends in South Korea. Environ Res. 2023; 226(Pt 1): 115657.
- Schüz J, Pirie K, Reeves GK, et al. Million Women Study Collaborators. Cellular Telephone Use and the Risk of Brain Tumors: Update of the UK Million Women Study. J Natl Cancer Inst. 2022; 114(5): 704–711.
- Feychting M, Schüz J, Toledano MB, et al. Mobile phone use and brain tumour risk - COSMOS, a prospective cohort study. Environ Int. 2024; 185: 108552.
- Villeneuve PJ, Momoli F, Parent MÉ, et al. Cell phone use and the risk of glioma: are case-control study findings consistent with Canadian time trends in cancer incidence? Environ Res. 2021; 200: 111283.
- Choi KH, Ha J, Bae S, et al. Mobile Phone Use and Time Trend of Brain Cancer Incidence Rate in Korea. Bioelectromagnetics. 2021; 42(8): 629–648.
- Yoon S, Choi JW, Lee E, et al. Mobile phone use and risk of glioma: a case-control study in Korea for 2002-2007. Environ Health Toxicol. 2015; 30: e2015015.
- Karipidis K, Elwood M, Benke G, et al. Mobile phone use and incidence of brain tumour histological types, grading or anatomical location: a population-based ecological study. BMJ Open. 2018; 8(12): e024489.
- Elwood JM, Win SS, Aye PS, et al. Trends in brain cancers (glioma) in New Zealand from 1995 to 2020, with reference to mobile phone use. Cancer Epidemiol. 2022; 80: 102234.
- Uddin M, Dhanta R, Pitti T, et al. Incidence and Mortality of Malignant Brain Tumors after 20 Years of Mobile Use. Cancers (Basel). 2023; 15(13).
- Deltour I, Poulsen AH, Johansen C, et al. Time trends in mobile phone use and glioma incidence among males in the Nordic Countries, 1979-2016. Environ Int. 2022; 168: 107487.
- Shrestha M, Raitanen J, Salminen T, et al. Pituitary tumor risk in relation to mobile phone use: A case-control study. Acta Oncol. 2015; 54(8): 1159–1165.
- Pettersson D, Bottai M, Mathiesen T, et al. Long-term mobile phone use and acoustic neuroma risk. Epidemiology. 2014; 25(2): 233–241.
- Carlberg M, Hardell L. Pooled analysis of Swedish case-control studies during 1997-2003 and 2007-2009 on meningioma risk associated with the use of mobile and cordless phones. Oncol Rep. 2015; 33(6): 3093–3098.
- Coureau G, Leffondre K, Gruber A, et al. Mobile phone use and brain tumours in the CERENAT case-control study. Occup Environ Med. 2014; 71(7): 514–522.
- Momoli F, Siemiatycki J, McBride ML, et al. Probabilistic Multiple-Bias Modeling Applied to the Canadian Data From the Interphone Study of Mobile Phone Use and Risk of Glioma, Meningioma, Acoustic Neuroma, and Parotid Gland Tumors. Am J Epidemiol. 2017; 186(7): 885–893.
- Hardell L, Carlberg M. Mobile phones, cordless phones and rates of brain tumors in different age groups in the Swedish National Inpatient Register and the Swedish Cancer Register during 1998-2015. PLoS One. 2017; 12(10): e0185461.
- de Vocht F. Inferring the 1985-2014 impact of mobile phone use on selected brain cancer subtypes using Bayesian structural time series and synthetic controls. Environ Int. 2016; 97: 100–107.
- Grell K, Frederiksen K, Schüz J, et al. The Intracranial Distribution of Gliomas in Relation to Exposure From Mobile Phones: Analyses From the INTERPHONE Study. Am J Epidemiol. 2016; 184(11): 818–828.
- Carlberg M, Hardell L. Decreased survival of glioma patients with astrocytoma grade IV (glioblastoma multiforme) associated with long-term use of mobile and cordless phones. Int J Environ Res Public Health. 2014; 11(10): 10790–10805.
- Castaño-Vinyals G, Sadetzki S, Vermeulen R, et al. Wireless phone use in childhood and adolescence and neuroepithelial brain tumours: Results from the international MOBI-Kids study. Environ Int. 2022; 160: 107069.
- Sato Y, Kojimahara N, Yamaguchi N, et al. Analysis of mobile phone use among young patients with brain tumors in Japan. Bioelectromagnetics. 2017; 38(5): 349–355.
- Röösli M, Lagorio S, Schoemaker MJ, et al. Brain and Salivary Gland Tumors and Mobile Phone Use: Evaluating the Evidence from Various Epidemiological Study Designs. Annu Rev Public Health. 2019; 40: 221–238.
