Advances in Palliative Medicine 2002;1(2):57-66.
Vol 1, No 2 (2002): Polish Palliative Medicine
Artykuły poglądowe
Published online: 2002-06-04
Abstract
Paraneoplastic syndromes are group of conditions that are related to cancer, but not caused directly either by
local invasion or metastatic spread. They occur in 5–10% of patients with cancer and their incidence varies
depending on the tumour type and tumour stage. Paraneoplastic syndromes are important, because they
may be the presenting feature of a disease, can produce treatable symptoms (leading to better life quality),
may act as a marker of the therapeutic response. Finally, they may provide meaningful prognostic imformation.
The causes of paraneoplastic syndromes are not fully understood. However, two main mechanisms have been
identified: the first one is due to inappropriate hormonal or cytokine secretion, while the second is related to
the antitumour antibodies production that additionally react with normal tissue elements. Clinically most
frequent and important are the following paraneoplastic syndromes: constitutional symptoms (cancer cachexia,
fatigue and fever), numerous neurological syndromes (eg. Lambert-Eaton myasthenic syndrome, cerebellar
degeneration, retinopathy, encephalomyelitis), haematological disorders (eg. anaemia of chronic disease,
neutrophilia, thrombocytosis), disorders of haemostasis (eg. disseminated intravascular coagulation), rheumatic
conditions (eg. hypertrophic osteoarthropathy) and multiple skin syndromes (eg. disorders of pigmentation,
erythematous conditions). Of particular importance is paraneoplastic origin of several metabolic syndromes
(eg. hypercalcaemia and hyponatremia). The underlying mechanisms, clinical picture and management
of most important paraneoplastic syndromes are presented in this overview.
Abstract
Paraneoplastic syndromes are group of conditions that are related to cancer, but not caused directly either by
local invasion or metastatic spread. They occur in 5–10% of patients with cancer and their incidence varies
depending on the tumour type and tumour stage. Paraneoplastic syndromes are important, because they
may be the presenting feature of a disease, can produce treatable symptoms (leading to better life quality),
may act as a marker of the therapeutic response. Finally, they may provide meaningful prognostic imformation.
The causes of paraneoplastic syndromes are not fully understood. However, two main mechanisms have been
identified: the first one is due to inappropriate hormonal or cytokine secretion, while the second is related to
the antitumour antibodies production that additionally react with normal tissue elements. Clinically most
frequent and important are the following paraneoplastic syndromes: constitutional symptoms (cancer cachexia,
fatigue and fever), numerous neurological syndromes (eg. Lambert-Eaton myasthenic syndrome, cerebellar
degeneration, retinopathy, encephalomyelitis), haematological disorders (eg. anaemia of chronic disease,
neutrophilia, thrombocytosis), disorders of haemostasis (eg. disseminated intravascular coagulation), rheumatic
conditions (eg. hypertrophic osteoarthropathy) and multiple skin syndromes (eg. disorders of pigmentation,
erythematous conditions). Of particular importance is paraneoplastic origin of several metabolic syndromes
(eg. hypercalcaemia and hyponatremia). The underlying mechanisms, clinical picture and management
of most important paraneoplastic syndromes are presented in this overview.
Keywords
malignant tumours; paraneoplastic syndromes
Keywords
malignant tumours
paraneoplastic syndromes
Authors
Maciej Krzakowski