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Vol 2, No 1 (2003): Polish Palliative Medicine
Original articles
Published online: 2002-10-30
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The changes of reflex ventilatory response to hypercapnia in obstructive sleep apnea patients

Jacek J. Klawe, Małgorzata Tafil-Klawe, Adriana Laudencka, Małgorzata Szady-Grad, Monika Siekierka, Ilona Miśkowiec, Anna Grabowska-Gaweł, Wojciech Sikorski
Advances in Palliative Medicine 2003;2(1):5-8.

open access

Vol 2, No 1 (2003): Polish Palliative Medicine
Original articles
Published online: 2002-10-30

Abstract

The reflex ventilatory response to progressive hyperoxic hypercapnia was studied in three groups of obstructive sleep apnea patients. In patients with normal end-tidal PACO2 no differences were found as compared with the control group. Patients with inreased end-tidal PACO2 showed an impaired ventilatory response to hypercapnia, occuring on a background elevation of the arterial carbon dioxid: 1. the right shift with the normal slope of the regression curve of relationship between end-tidal PACO2 and minute ventilation and 2. the right shift with decrease of slope of the regression curve of relationship between end-tidal PACO2 and minute ventilation. Patients, who develop hypercapnic respiratory failure awake, showed an impaired hypercapnic defence reaction.

Abstract

The reflex ventilatory response to progressive hyperoxic hypercapnia was studied in three groups of obstructive sleep apnea patients. In patients with normal end-tidal PACO2 no differences were found as compared with the control group. Patients with inreased end-tidal PACO2 showed an impaired ventilatory response to hypercapnia, occuring on a background elevation of the arterial carbon dioxid: 1. the right shift with the normal slope of the regression curve of relationship between end-tidal PACO2 and minute ventilation and 2. the right shift with decrease of slope of the regression curve of relationship between end-tidal PACO2 and minute ventilation. Patients, who develop hypercapnic respiratory failure awake, showed an impaired hypercapnic defence reaction.
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Keywords

obstructive sleep apnea; the ventilatory response to hypercapnia

About this article
Title

The changes of reflex ventilatory response to hypercapnia in obstructive sleep apnea patients

Journal

Advances in Palliative Medicine

Issue

Vol 2, No 1 (2003): Polish Palliative Medicine

Pages

5-8

Published online

2002-10-30

Bibliographic record

Advances in Palliative Medicine 2003;2(1):5-8.

Keywords

obstructive sleep apnea
the ventilatory response to hypercapnia

Authors

Jacek J. Klawe
Małgorzata Tafil-Klawe
Adriana Laudencka
Małgorzata Szady-Grad
Monika Siekierka
Ilona Miśkowiec
Anna Grabowska-Gaweł
Wojciech Sikorski

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