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open access

Vol 2, No 1 (2003): Polish Palliative Medicine
Artykuły poglądowe
Published online: 2002-10-30
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The mechanisms of pain. Pain neurophisiology for beginners

Zbigniew Żylicz, Małgorzata Krajnik
Advances in Palliative Medicine 2003;2(1):49-56.

open access

Vol 2, No 1 (2003): Polish Palliative Medicine
Artykuły poglądowe
Published online: 2002-10-30

Abstract

This article will first review the evidence of the molecular mechanisms by which different classes of nociceptors respond to novious stimuli at their peripheral terminals and convert these stimuli into signals transmitted to the central nervous system. Second, the article will describe cellular and molecular signaling pathways that underlie the sensitization of these transduction mechanisms during inflammation and nerve injury and how these processes may underlie the generation and maintenance of chronic pain.

Abstract

This article will first review the evidence of the molecular mechanisms by which different classes of nociceptors respond to novious stimuli at their peripheral terminals and convert these stimuli into signals transmitted to the central nervous system. Second, the article will describe cellular and molecular signaling pathways that underlie the sensitization of these transduction mechanisms during inflammation and nerve injury and how these processes may underlie the generation and maintenance of chronic pain.
Get Citation

Keywords

chronic pain; patophysiology; endogenous opioids; spinal sensitization; neuropathic pain

About this article
Title

The mechanisms of pain. Pain neurophisiology for beginners

Journal

Advances in Palliative Medicine

Issue

Vol 2, No 1 (2003): Polish Palliative Medicine

Pages

49-56

Published online

2002-10-30

Bibliographic record

Advances in Palliative Medicine 2003;2(1):49-56.

Keywords

chronic pain
patophysiology
endogenous opioids
spinal sensitization
neuropathic pain

Authors

Zbigniew Żylicz
Małgorzata Krajnik

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