The mechanisms of pain. Pain neurophisiology for beginners

Zbigniew Żylicz; Małgorzata Krajnik

Vol 2, No 1 (2003): Polish Palliative Medicine

Artykuły poglądowe

Published online: 2002-10-30

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The mechanisms of pain. Pain neurophisiology for beginners

Zbigniew Żylicz, Małgorzata Krajnik

Advances in Palliative Medicine 2003;2(1):49-56.

Vol 2, No 1 (2003): Polish Palliative Medicine

Artykuły poglądowe

Published online: 2002-10-30

Abstract

This article will first review the evidence of the molecular mechanisms by which different classes of nociceptors respond to novious stimuli at their peripheral terminals and convert these stimuli into signals transmitted to the central nervous system. Second, the article will describe cellular and molecular signaling pathways that underlie the sensitization of these transduction mechanisms during inflammation and nerve injury and how these processes may underlie the generation and maintenance of chronic pain.