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Vol 2, No 2 (2003): Polish Palliative Medicine
Leki w medycynie paliatywnej
Published online: 2003-02-05
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Cannabinoids in palliative medicine

Małgorzata Krajnik, Zbigniew Żylicz
Advances in Palliative Medicine 2003;2(2):123-131.

open access

Vol 2, No 2 (2003): Polish Palliative Medicine
Leki w medycynie paliatywnej
Published online: 2003-02-05

Abstract


Currently there is a heightened interest in the analgesic potential of cannabinoid receptor agonists such as tetrahydrocannabinol (D-9-THC) and synthetic agonists. There is a need for an improved understanding of the sites of cannabinoid receptors and mechanisms by which cannabinoids affect central and peripheral nervous system. Apart from analgesia, cannabinoids may find a place for example in the treatment of anorexia-cachexia, spasticity, dyspnea, or glaucoma. Presently, concerns about the quality, efficacy and safety of cannabinoids prevent clinical use. It is anticipated that developments in pharmaceutical agents and formulations should overcome these clinical difficulties.

Abstract


Currently there is a heightened interest in the analgesic potential of cannabinoid receptor agonists such as tetrahydrocannabinol (D-9-THC) and synthetic agonists. There is a need for an improved understanding of the sites of cannabinoid receptors and mechanisms by which cannabinoids affect central and peripheral nervous system. Apart from analgesia, cannabinoids may find a place for example in the treatment of anorexia-cachexia, spasticity, dyspnea, or glaucoma. Presently, concerns about the quality, efficacy and safety of cannabinoids prevent clinical use. It is anticipated that developments in pharmaceutical agents and formulations should overcome these clinical difficulties.
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Keywords

cannabinoids; CB1 receptor; CB2 receptor; analgesia; immunomodulation

About this article
Title

Cannabinoids in palliative medicine

Journal

Advances in Palliative Medicine

Issue

Vol 2, No 2 (2003): Polish Palliative Medicine

Pages

123-131

Published online

2003-02-05

Bibliographic record

Advances in Palliative Medicine 2003;2(2):123-131.

Keywords

cannabinoids
CB1 receptor
CB2 receptor
analgesia
immunomodulation

Authors

Małgorzata Krajnik
Zbigniew Żylicz

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