Background. Recipe proceeding form of preparation for transdermal application containing morphine sulphate bring into effect during curration of painful skin and mucosa ulceration. Assume, that pharmacotherapeutic efficacy is determinated by physicochemical characteristic of biological activity of substance and base composition, investigations have been made to check the diffusion rate of morphine sulphate from developed preparations.
Materials and methods. In a recipe proceeding mode there were developed alternative forms of preparations for transdermal applications i.e. hydrogel and ointment of an absorption cream type (water/oil) with transdermal transition promotors of morphine sulphate content ~0,2%. The preparations were characterized by a practical density (dp), hydrogen ion activity (a_H+, pH) and above all by a smear constant determined by rheological measurements (visco-elasticity measurements). There has been investigated, according to the requirements of European Pharmacopoeia, the diffusion rate of morphine sulfate from the preparations directly to the external compartment (compensation fluid) and through semi-permeable membranes of Servapol and Visking type making a model stratum corneum.
Results and conclusions. Investigations shows, according to interaction between morphine sulphate and different base compositions, that we receive different rheological adhesives of preparations. Acidity (pH) levels in developed substances were included in physiological tolerance limits of skin and mucosa. Addition oksyethylated lanolin to I^a and I^b ointment used as a transdermal transition promotor contributes to accelerate diffusion of morphine sulphate to the external compartment. The kinetic of releasing morphine sulphate in first 10 min. of exposition reached maximum for hydrogel preparation 0,2% H. We should expect that after using this hydrogel preparation analgesia appears fastest. Diffusion rate of morphine sulphate through semi-permeable membranes of Servapol and Visking type making a model stratum corneum were slower, that’s probably is connected with high moll mass of the hydrotropic morphine adduct.