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Vol 2, No 3 (2003): Polish Palliative Medicine
Artykuły poglądowe
Published online: 2003-05-29
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How do opioids work in dyspnoea?

Małgorzata Krajnik, Zbigniew Żylicz, Anna Adamczyk
Advances in Palliative Medicine 2003;2(3):183-190.

open access

Vol 2, No 3 (2003): Polish Palliative Medicine
Artykuły poglądowe
Published online: 2003-05-29

Abstract

Opioids are commonly used to treat dyspnoea in advanced cancer. The place of opioids for COPD patients in dyspnoea is still discussed. Morphine is an opioid of choice for treatment of breathlessness. Its efficacy mostly depends on reduction of the ventilatory response to hypercapnia, hypoxia and exercise. Other mechanisms due to the action on opioid receptors in alveoli, in the wall of trachea and bronchi, systemic venodilatation, analgesia, or reduction of enhanced peripheral chemosensitivity, may be also important in specific clinical situations. Recent systematic review concluded that oral and parenteral but not nebulised opioids improved breathlessness.

Abstract

Opioids are commonly used to treat dyspnoea in advanced cancer. The place of opioids for COPD patients in dyspnoea is still discussed. Morphine is an opioid of choice for treatment of breathlessness. Its efficacy mostly depends on reduction of the ventilatory response to hypercapnia, hypoxia and exercise. Other mechanisms due to the action on opioid receptors in alveoli, in the wall of trachea and bronchi, systemic venodilatation, analgesia, or reduction of enhanced peripheral chemosensitivity, may be also important in specific clinical situations. Recent systematic review concluded that oral and parenteral but not nebulised opioids improved breathlessness.
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Keywords

opioids; breathlessness; cancer; COPD

About this article
Title

How do opioids work in dyspnoea?

Journal

Advances in Palliative Medicine

Issue

Vol 2, No 3 (2003): Polish Palliative Medicine

Pages

183-190

Published online

2003-05-29

Bibliographic record

Advances in Palliative Medicine 2003;2(3):183-190.

Keywords

opioids
breathlessness
cancer
COPD

Authors

Małgorzata Krajnik
Zbigniew Żylicz
Anna Adamczyk

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