Shortcuts

open access

Vol 3, No 1 (2004): Polish Palliative Medicine
Case reports
Published online: 2003-10-27
Get Citation

Opioid induced hyperalgesia and effects of low doses of naloxone

Zbigniew Żylicz
Advances in Palliative Medicine 2004;3(1):67-70.

open access

Vol 3, No 1 (2004): Polish Palliative Medicine
Case reports
Published online: 2003-10-27

Abstract

Opioids are used for their pain relieving, analgesic effect. However in some patients the same drugs are able to act in opposite way and to induce hyperalgesia. This opioid induced hyperalgesia is responsible for development of tolerance to opioids. In the case report presented here, we observed development of tolerance to fetanyl, accompanied by marked delirium. Ultra low doses of naloxone (0.20 mg/24 hours) are known to inhibit opioid receptors being in excitatory mode. This treatment resulted in rapid improvement of both analgesia and of cognitive functions. The meaning of this observation and explanation of this phenomenon are discussed in detail.

Abstract

Opioids are used for their pain relieving, analgesic effect. However in some patients the same drugs are able to act in opposite way and to induce hyperalgesia. This opioid induced hyperalgesia is responsible for development of tolerance to opioids. In the case report presented here, we observed development of tolerance to fetanyl, accompanied by marked delirium. Ultra low doses of naloxone (0.20 mg/24 hours) are known to inhibit opioid receptors being in excitatory mode. This treatment resulted in rapid improvement of both analgesia and of cognitive functions. The meaning of this observation and explanation of this phenomenon are discussed in detail.
Get Citation

Keywords

pain; opioid inducted hyperalgesia; naloxone

About this article
Title

Opioid induced hyperalgesia and effects of low doses of naloxone

Journal

Advances in Palliative Medicine

Issue

Vol 3, No 1 (2004): Polish Palliative Medicine

Pages

67-70

Published online

2003-10-27

Bibliographic record

Advances in Palliative Medicine 2004;3(1):67-70.

Keywords

pain
opioid inducted hyperalgesia
naloxone

Authors

Zbigniew Żylicz

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail:  viamedica@viamedica.pl