Shortcuts

open access

Vol 4, No 1 (2005): Polish Palliative Medicine
Original articles
Published online: 2005-01-19
Get Citation

The cancer cachexia syndrome. The influence of treatment on selected clinical and biochemical parameters. Preliminary report

Maciej Bączyk, Lidia Gorzelińska, Jacek Łuczak, Jerzy Sowiński
Advances in Palliative Medicine 2005;4(1):11-16.

open access

Vol 4, No 1 (2005): Polish Palliative Medicine
Original articles
Published online: 2005-01-19

Abstract

The aim of the study was to establish the correlation between the grade of cachexia and possible endocrine factors and the type of therapy. Disturbances of thyroxin conversion to triiodothyronine - low T3 syndrome, high revers-T3 values, low insulin and IGF-1 levels. The statistically significant, positive correlation between weight loss and anorexia (p < 0.01), pain intensity (p < 0.01), grade of depression (p < 0.01), higher values of cortisol (p < 0.05) was detected. In the examined group, in spite of tendency, correlation between the grade of weight loss and IL-6 or TNFα values was not observed. The obtained results indicate, that cancer cachexia is the result of multiple factors. Chronic, higher than normal, cortisol level induces the depression, protein degradation (together with TNFα, especially in skeletal muscles mass), lipolysis, higher liver glucose production and gluconeogenesis; together with cytokines leads to insulin resistance, tendency to postprandial hyperglycaemia, which inhibits appetite after small meal administration. The progestins are the most effective agents in the treatment of cancer cachexia, but good symptoms control, psychic state of patient are also very important.

Abstract

The aim of the study was to establish the correlation between the grade of cachexia and possible endocrine factors and the type of therapy. Disturbances of thyroxin conversion to triiodothyronine - low T3 syndrome, high revers-T3 values, low insulin and IGF-1 levels. The statistically significant, positive correlation between weight loss and anorexia (p < 0.01), pain intensity (p < 0.01), grade of depression (p < 0.01), higher values of cortisol (p < 0.05) was detected. In the examined group, in spite of tendency, correlation between the grade of weight loss and IL-6 or TNFα values was not observed. The obtained results indicate, that cancer cachexia is the result of multiple factors. Chronic, higher than normal, cortisol level induces the depression, protein degradation (together with TNFα, especially in skeletal muscles mass), lipolysis, higher liver glucose production and gluconeogenesis; together with cytokines leads to insulin resistance, tendency to postprandial hyperglycaemia, which inhibits appetite after small meal administration. The progestins are the most effective agents in the treatment of cancer cachexia, but good symptoms control, psychic state of patient are also very important.
Get Citation

Keywords

cancer cachexia; cortisol; cytokines; progestins

About this article
Title

The cancer cachexia syndrome. The influence of treatment on selected clinical and biochemical parameters. Preliminary report

Journal

Advances in Palliative Medicine

Issue

Vol 4, No 1 (2005): Polish Palliative Medicine

Pages

11-16

Published online

2005-01-19

Bibliographic record

Advances in Palliative Medicine 2005;4(1):11-16.

Keywords

cancer cachexia
cortisol
cytokines
progestins

Authors

Maciej Bączyk
Lidia Gorzelińska
Jacek Łuczak
Jerzy Sowiński

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail:  viamedica@viamedica.pl