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Vol 4, No 1 (2005): Polish Palliative Medicine
Case reports
Published online: 2005-01-19
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Pruritus of cholestasis in patient with advanced neoplasmatic disease. Case report

Michał Graczyk, Małgorzata Krajnik, Krzysztof Ostrowski
Advances in Palliative Medicine 2005;4(1):24-27.

open access

Vol 4, No 1 (2005): Polish Palliative Medicine
Case reports
Published online: 2005-01-19

Abstract

Severe pruritus is frequently seen in cholestasis due to advanced cancer. According to evidence of a role of endogenous opioids and serotonin, the most effective drugs in the treatment of pruritus are opioid and serotonin receptors antagonists. We describe a patient with advanced colon cancer and liver metastases, in whom pruritus didn’t disappear after stenting of the common bile duct. Small dose of paroxetine gradually in several days decreased the intensity of itch significantly enough to promote skin healing.

Abstract

Severe pruritus is frequently seen in cholestasis due to advanced cancer. According to evidence of a role of endogenous opioids and serotonin, the most effective drugs in the treatment of pruritus are opioid and serotonin receptors antagonists. We describe a patient with advanced colon cancer and liver metastases, in whom pruritus didn’t disappear after stenting of the common bile duct. Small dose of paroxetine gradually in several days decreased the intensity of itch significantly enough to promote skin healing.
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Keywords

cancer; cholestasis; serotonin; paroxetine

About this article
Title

Pruritus of cholestasis in patient with advanced neoplasmatic disease. Case report

Journal

Advances in Palliative Medicine

Issue

Vol 4, No 1 (2005): Polish Palliative Medicine

Pages

24-27

Published online

2005-01-19

Bibliographic record

Advances in Palliative Medicine 2005;4(1):24-27.

Keywords

cancer
cholestasis
serotonin
paroxetine

Authors

Michał Graczyk
Małgorzata Krajnik
Krzysztof Ostrowski

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