open access
Vol 5, No 2 (2006): Polish Palliative Medicine
Artykuły poglądowe
Published online: 2006-05-25
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Opioid-induced hyperalgesia
Advances in Palliative Medicine 2006;5(2):76-81.
open access
Vol 5, No 2 (2006): Polish Palliative Medicine
Artykuły poglądowe
Published online: 2006-05-25
Abstract
Recently it became clear that opioids, besides their role in analgesia, mayalso induce hyperalgesia. Something
what in the past was called opioidneurotoxicity. Hyperalgesia, or hypersensitivity to pain stimuli may
berelated to well known problems of tolerance to opioids. Hyperalgesia is amajor clinical problem and its
recognition and treatment are of paramountimportance. It is believed that uncoupling of opioid receptors
from theGi/Go proteins and coupling them to Gs protein changes dramatically activityof opioid receptors. In
this article the different aspects of diagnosis andtreatment of hyperalgesia are discussed.
Abstract
Recently it became clear that opioids, besides their role in analgesia, mayalso induce hyperalgesia. Something
what in the past was called opioidneurotoxicity. Hyperalgesia, or hypersensitivity to pain stimuli may
berelated to well known problems of tolerance to opioids. Hyperalgesia is amajor clinical problem and its
recognition and treatment are of paramountimportance. It is believed that uncoupling of opioid receptors
from theGi/Go proteins and coupling them to Gs protein changes dramatically activityof opioid receptors. In
this article the different aspects of diagnosis andtreatment of hyperalgesia are discussed.
Get Citation
Keywords
opioids; hyperalgesia
About this articleTitle
Opioid-induced hyperalgesia
Journal
Advances in Palliative Medicine
Issue
Vol 5, No 2 (2006): Polish Palliative Medicine
Pages
76-81
Published online
2006-05-25
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1476
Article views/downloads
1619
Bibliographic record
Advances in Palliative Medicine 2006;5(2):76-81.
Keywords
opioids
hyperalgesia
Authors
Sebastiano Mercadante