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Vol 5, No 4 (2006): Polish Palliative Medicine
Original articles
Published online: 2007-01-15
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Fast and simple method of morphine extraction from the blood

Małgorzata Krajnik, Marzena Sykutera, Ewa Pufal
Advances in Palliative Medicine 2006;5(4):173-176.

open access

Vol 5, No 4 (2006): Polish Palliative Medicine
Original articles
Published online: 2007-01-15

Abstract


Background/Material and methods. In this study we evaluated the efficiency of morphine extraction from the whole blood by liquid-liquid methods using three types of organic solvents.
Results. The highest average recovery rate was observed for the 9:1 mixture of isopropanol and chloroform (92.5%). Lower, but still satisfactory, recovery rate was observed for acetonitril (72.7%) and dichloromethane (67.1%).
Conclusions. Isolation of morphine from the whole blood by simple solvent extraction with isopropanol-chloroform mixture is fast, efficient and easily accessible for each laboratory.

Abstract


Background/Material and methods. In this study we evaluated the efficiency of morphine extraction from the whole blood by liquid-liquid methods using three types of organic solvents.
Results. The highest average recovery rate was observed for the 9:1 mixture of isopropanol and chloroform (92.5%). Lower, but still satisfactory, recovery rate was observed for acetonitril (72.7%) and dichloromethane (67.1%).
Conclusions. Isolation of morphine from the whole blood by simple solvent extraction with isopropanol-chloroform mixture is fast, efficient and easily accessible for each laboratory.
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Keywords

morphine; whole blood; extraction recovery rate

About this article
Title

Fast and simple method of morphine extraction from the blood

Journal

Advances in Palliative Medicine

Issue

Vol 5, No 4 (2006): Polish Palliative Medicine

Pages

173-176

Published online

2007-01-15

Bibliographic record

Advances in Palliative Medicine 2006;5(4):173-176.

Keywords

morphine
whole blood
extraction recovery rate

Authors

Małgorzata Krajnik
Marzena Sykutera
Ewa Pufal

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