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Vol 5, No 4 (2006): Polish Palliative Medicine
Original articles
Published online: 2007-01-15
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Evaluation of analgesia and adverse events of methadone in hemodialyzed patients with chronic kidney disease

Michał Graczyk, Małgorzata Krajnik, Paweł Stróżecki, Jacek Manitius
Advances in Palliative Medicine 2006;5(4):167-172.

open access

Vol 5, No 4 (2006): Polish Palliative Medicine
Original articles
Published online: 2007-01-15

Abstract

Patients with chronic renal failure, also on dialysis, frequently suffer(ed) from various intractable pain syndromes. Methadone has been proposed to be an especially useful opioid for such patients due to its predominant intestinal elimination in uraemia, inactive metabolites, and because it is not dialyzed. The aim of this study was to analyze the analgesic efficacy and safety of methadone in patients with renal failure. Methadone efficiently diminished different pain syndromes in 5 hemodialyzed patients. Initial doses were small, individually chosen and carefully titrated. Sedation as the main adverse event was successfully ameliorated by decrease of methadone dose.

Abstract

Patients with chronic renal failure, also on dialysis, frequently suffer(ed) from various intractable pain syndromes. Methadone has been proposed to be an especially useful opioid for such patients due to its predominant intestinal elimination in uraemia, inactive metabolites, and because it is not dialyzed. The aim of this study was to analyze the analgesic efficacy and safety of methadone in patients with renal failure. Methadone efficiently diminished different pain syndromes in 5 hemodialyzed patients. Initial doses were small, individually chosen and carefully titrated. Sedation as the main adverse event was successfully ameliorated by decrease of methadone dose.
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Keywords

methadone; chronic kidney disease (CKD); dialysis patients

About this article
Title

Evaluation of analgesia and adverse events of methadone in hemodialyzed patients with chronic kidney disease

Journal

Advances in Palliative Medicine

Issue

Vol 5, No 4 (2006): Polish Palliative Medicine

Pages

167-172

Published online

2007-01-15

Bibliographic record

Advances in Palliative Medicine 2006;5(4):167-172.

Keywords

methadone
chronic kidney disease (CKD)
dialysis patients

Authors

Michał Graczyk
Małgorzata Krajnik
Paweł Stróżecki
Jacek Manitius

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