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Vol 5, No 4 (2006): Polish Palliative Medicine
Original articles
Published online: 2007-01-15
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Comparison of different methods of morphine inhalation in dyspnoea and cough

Małgorzata Krajnik, Zygmunt Podolec
Advances in Palliative Medicine 2006;5(4):145-153.

open access

Vol 5, No 4 (2006): Polish Palliative Medicine
Original articles
Published online: 2007-01-15

Abstract


Background. Preliminary results of opioid receptor visualization in human lung suggest that morphine might have different mechanisms of action depending on whether it reaches the bronchial epithelium or alveoli.
Methods. The aim of the present study was to create and compare two pneumodosimetric methods of morphine inhalation to receive high drug deposition either in central or peripheral respiratory tract. To do so, we produced particles of different diameters and applied aerosol to certain volume of inspired air.
Results and conclusions. Bronchial control treatment system - Sidestream (BCTS-S) which produced larger particles and administered drugs only to the second (50-75%) part of inspiration seems to be an optimal method for delivering morphine near opioid receptors in the bronchial epithelium. In bronchial control treatment system - Micro Cirrus (BCTS-MC) characterized by small particles and aerosol given at the beginning of inspiration we can expect high deposition of drug in the alveoli. In the second part of the study, the aerosol particle distribution was assessed for BCTS-S and BCTS-MC and related 2 pneumatic methods (IP-S and IP-MC, respectively). In all cases, 100% particles were smaller than 5.5 µm which suggest they can reach the respiratory tract. In BCTS-MC and IP-MC 100% aerosol particles had diameter lower than 3.5 µm, which vote for possibility of preferential deposition in peripheral respiratory tract.

Abstract


Background. Preliminary results of opioid receptor visualization in human lung suggest that morphine might have different mechanisms of action depending on whether it reaches the bronchial epithelium or alveoli.
Methods. The aim of the present study was to create and compare two pneumodosimetric methods of morphine inhalation to receive high drug deposition either in central or peripheral respiratory tract. To do so, we produced particles of different diameters and applied aerosol to certain volume of inspired air.
Results and conclusions. Bronchial control treatment system - Sidestream (BCTS-S) which produced larger particles and administered drugs only to the second (50-75%) part of inspiration seems to be an optimal method for delivering morphine near opioid receptors in the bronchial epithelium. In bronchial control treatment system - Micro Cirrus (BCTS-MC) characterized by small particles and aerosol given at the beginning of inspiration we can expect high deposition of drug in the alveoli. In the second part of the study, the aerosol particle distribution was assessed for BCTS-S and BCTS-MC and related 2 pneumatic methods (IP-S and IP-MC, respectively). In all cases, 100% particles were smaller than 5.5 µm which suggest they can reach the respiratory tract. In BCTS-MC and IP-MC 100% aerosol particles had diameter lower than 3.5 µm, which vote for possibility of preferential deposition in peripheral respiratory tract.
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Keywords

morphine; pneumodosimeter; inhalation; aerosol particle

About this article
Title

Comparison of different methods of morphine inhalation in dyspnoea and cough

Journal

Advances in Palliative Medicine

Issue

Vol 5, No 4 (2006): Polish Palliative Medicine

Pages

145-153

Published online

2007-01-15

Bibliographic record

Advances in Palliative Medicine 2006;5(4):145-153.

Keywords

morphine
pneumodosimeter
inhalation
aerosol particle

Authors

Małgorzata Krajnik
Zygmunt Podolec

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