The effect of gabapentin and pregabalin on symptoms other than pain and seizures. A review of the evidence

Zbigniew Zylicz; Małgorzata Krajnik

Vol 7, No 4 (2008)

Review articles

Published online: 2008-10-21

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The effect of gabapentin and pregabalin on symptoms other than pain and seizures. A review of the evidence

Zbigniew Zylicz, Małgorzata Krajnik

Advances in Palliative Medicine 2008;7(4):179-184.

Vol 7, No 4 (2008)

Review articles

Published online: 2008-10-21

Abstract

Gabapentin and pregabalin are drugs that act through reduction of the central sensitization. They are useful in conditions such as partial seizures and neuropathic pain. However, in the last decade these drugs appear to have been effective against a variety of other symptoms, such as pruritus, hot flushes in post-menopausal women and intractable hiccups. The drugs are probably also effective for many other symptoms related to central sensitization but the paucity of data does not allow for support of these claims. Both gabapentin and pregabalin have a good safety record.