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open access

Vol 7, No 4 (2008)
Review articles
Published online: 2008-10-21
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The effect of gabapentin and pregabalin on symptoms other than pain and seizures. A review of the evidence

Zbigniew Zylicz, Małgorzata Krajnik
Advances in Palliative Medicine 2008;7(4):179-184.

open access

Vol 7, No 4 (2008)
Review articles
Published online: 2008-10-21

Abstract

Gabapentin and pregabalin are drugs that act through reduction of the central sensitization. They are useful in conditions such as partial seizures and neuropathic pain. However, in the last decade these drugs appear to have been effective against a variety of other symptoms, such as pruritus, hot flushes in post-menopausal women and intractable hiccups. The drugs are probably also effective for many other symptoms related to central sensitization but the paucity of data does not allow for support of these claims. Both gabapentin and pregabalin have a good safety record.

Abstract

Gabapentin and pregabalin are drugs that act through reduction of the central sensitization. They are useful in conditions such as partial seizures and neuropathic pain. However, in the last decade these drugs appear to have been effective against a variety of other symptoms, such as pruritus, hot flushes in post-menopausal women and intractable hiccups. The drugs are probably also effective for many other symptoms related to central sensitization but the paucity of data does not allow for support of these claims. Both gabapentin and pregabalin have a good safety record.
Get Citation

Keywords

gabapentin; pregabalin; nausea; vomiting; pruritus; restless legs syndrome; hot flushes; sweating; hiccup; tinnitus

About this article
Title

The effect of gabapentin and pregabalin on symptoms other than pain and seizures. A review of the evidence

Journal

Advances in Palliative Medicine

Issue

Vol 7, No 4 (2008)

Pages

179-184

Published online

2008-10-21

Bibliographic record

Advances in Palliative Medicine 2008;7(4):179-184.

Keywords

gabapentin
pregabalin
nausea
vomiting
pruritus
restless legs syndrome
hot flushes
sweating
hiccup
tinnitus

Authors

Zbigniew Zylicz
Małgorzata Krajnik

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