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Standardizing blood dose using body surface area and analyze the effect of blood storage on hemoglobin increment within pediatric patients
Affiliations- Department of Transfusion Medicine and Blood Bank, All India Institute of Medical Sciences Raipur, GE Road Tatibandh Raipur Chhattisgarh India, 492099 Raipur, India
- Department of Pediatrics, All India Institute of Medical Sciences Raipur, Raipur (Chhattisgarh), India
- Biostatistician, Department of Community Medicine, All India Institute of Medical Sciences Raipur, Raipur (Chhattisgarh), India
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Abstract
Introduction: Pediatric patients exhibit a wide variation in weight which results in diverse transfusion practices. This study aims to standardize red blood cell (RBC) doses according to body surface area (BSA) and to analyze the role of RBC storage in post-transfusion hemoglobin levels.
Material and methods: In this original prospective cohort study on hospitalized pediatric patients aged up to 14, we classified patients into transfusion-dependent (n = 31) and non-transfusion-dependent (n = 158). The non-transfusiondependent group was further classified into ≤10 kg (n = 72) or >10 kg (n = 86) according to body weight (bw). We derived a regression equation between BSA and blood dose in non-transfusion-dependent subjects, and modified the equation by fixing blood dose to 15 mL/kg bw for only BSA based blood dose. We measured pre-transfusion and post-transfusion hemoglobin (Hb) levels, and ascertained effects of blood storage ≤15 days (n = 15) and >15 days (n = 16) on posttransfusion Hb.
Results: Pediatric patients ≤10 kg and >10 kg bw (n = 158); mean ± standard deviation of weight and BSA were 4.5 ± 3.1 kg; 22.9 ± 10.4 kg; 0.26 ± 0.14 m2; 0.9 ± 0.28) m2 respectively. The regression equation ≤10 kg and >10 kg bw when adjusted. Blood dose fixed at 15 mL/kg bw adjusted blood dose ≤10 kg; 15 mL/kg bw = −19.12 + 329.69x BSA m2. The regression equation >10 kg bw: adjusted blood dose >10 kg bw; 15 mL/kg bw = −158.8 + 563.3x BSA (m2). The adjusted blood dose with BSA did not exceed 20 mL/kg bw. No significant differences were observed in pre and post-transfusion Hb in transfusion-dependent (n = 31) versus non-transfusion-dependent patients (n = 158) due to the RBC storage duration.
Conclusions: RBC blood dose can be standardized by regression equation between standardized RBC dosage and BSA. Post-transfusion Hb is not dependent on days of RBC storage at the blood bank.
Abstract
Introduction: Pediatric patients exhibit a wide variation in weight which results in diverse transfusion practices. This study aims to standardize red blood cell (RBC) doses according to body surface area (BSA) and to analyze the role of RBC storage in post-transfusion hemoglobin levels.
Material and methods: In this original prospective cohort study on hospitalized pediatric patients aged up to 14, we classified patients into transfusion-dependent (n = 31) and non-transfusion-dependent (n = 158). The non-transfusiondependent group was further classified into ≤10 kg (n = 72) or >10 kg (n = 86) according to body weight (bw). We derived a regression equation between BSA and blood dose in non-transfusion-dependent subjects, and modified the equation by fixing blood dose to 15 mL/kg bw for only BSA based blood dose. We measured pre-transfusion and post-transfusion hemoglobin (Hb) levels, and ascertained effects of blood storage ≤15 days (n = 15) and >15 days (n = 16) on posttransfusion Hb.
Results: Pediatric patients ≤10 kg and >10 kg bw (n = 158); mean ± standard deviation of weight and BSA were 4.5 ± 3.1 kg; 22.9 ± 10.4 kg; 0.26 ± 0.14 m2; 0.9 ± 0.28) m2 respectively. The regression equation ≤10 kg and >10 kg bw when adjusted. Blood dose fixed at 15 mL/kg bw adjusted blood dose ≤10 kg; 15 mL/kg bw = −19.12 + 329.69x BSA m2. The regression equation >10 kg bw: adjusted blood dose >10 kg bw; 15 mL/kg bw = −158.8 + 563.3x BSA (m2). The adjusted blood dose with BSA did not exceed 20 mL/kg bw. No significant differences were observed in pre and post-transfusion Hb in transfusion-dependent (n = 31) versus non-transfusion-dependent patients (n = 158) due to the RBC storage duration.
Conclusions: RBC blood dose can be standardized by regression equation between standardized RBC dosage and BSA. Post-transfusion Hb is not dependent on days of RBC storage at the blood bank.
Keywords
body surface area, regression equation, RBC storage changes, dose banding
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About this articleTitle
Standardizing blood dose using body surface area and analyze the effect of blood storage on hemoglobin increment within pediatric patients
Journal
Issue
Article type
Original research article
Pages
285-292
Published online
2022-06-05
Page views
1753
Article views/downloads
104
DOI
10.5603/AHP.a2022.0029
Bibliographic record
Acta Haematol Pol 2022;53(4):285-292.
Keywords
body surface area
regression equation
RBC storage changes
dose banding
Authors
Sankalp Sharma
Sunil Jondhale
Mili Patel
Arvind Shukla
Anil Goel
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